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Home / Primary Antibodies / Phospho Antibodies

Anti-Zap70/Syk Antibody (Zap70Y493-H11) Unconjugated BHA10600162

SKU : BHA10600162

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Abwiz Bio Inc.

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Mfr.No.	1161
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	monoclonal
Description	ZAP70 (Tyrosine-protein kinase ZAP-70, phospho Zap70) is a protein tyrosine kinase (PTK) that associates with the z subunit of the T cell antigen receptor (TCR) and undergoes tyrosine phosphorylation following TCR stimulation. Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck. ZAP70 contains two SH2-like domains with the PTK domain located at the C-terminus. It appears that both phospho Zap70 and Syk are recruited to the phosphorylated CD3 and z subunits after TCR stimulation. Phosphorylation of Tyr319 is required for the assembly of a phospho Zap70-containing signaling complex that leads to the activation of the PLC-gamma1-dependent and Ras-dependent signaling cascades in antigen-stimulated T cells. The orthologous Tyr352 residue in Syk is also involved in the association with PLC-gamma1. Phosphorylation of Tyr493 within the activation loop results in enzymatic activation of phospho Zap70.
Host	Rabbit
Immunogen	A synthetic phospho-peptide corresponding to residues surrounding Tyr493 of human phospho Zap70
Isotype	IgG1 Kappa
Modification	Phospho-Tyr493, Phospho-Tyr526
Reactivity	Mouse, Human
Reregulatory	RUO

Clone No	Zap70Y493-H11

Buffer	1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Concentration	0.5mg/ml
Dilutions	1- 0.1 µg/ml
Storage	-20ºC

Applications	WB, FACS
Description	WB ; FACS

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SKU	Supplier No.	Size	Your price	Quantity
BHA10600162	1161	200µl	$488.10		Add to Cart
BHA10600162	1161	20µl	$196.67		Add to Cart

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