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Home / Primary Antibodies / Flow Cytometry (FACS)

Anti-Chk1 Antibody (Chk1S345-R3F9) Unconjugated BHA10600036

SKU : BHA10600036

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Abwiz Bio Inc.

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Mfr.No.	2191
Antigen	Chk1
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	monoclonal
Conjugate	Unconjugated
Description	The act of DNA damaged response and cell cycle checkpoints requires the activation of four protein kinases that form the canonical ATR-Chk1 and ATM-Chk2 pathways. ATR activation requires the generation of structures containing single strand DNA (ssDNA) adjacent to double strand DNA (dsDNA). Such ssDNA is coated with replication protein A complex and attracts ATR (1,2). The accumulation of ATR to damage sites results in initial activation of ATR. ATR phosphorylates proteins at the ssDNA which are called checkpoint regulators. The accumulation and phosphorylation of these checkpoint regulators further stimulates the catalytic activity of ATR. ATR-induced Chk1 phosphorylation likely occurs at the sites of DNA damage on chromatin (3-5). The activated ATR phosphorylates
Host	Rabbit
Immunogen	A synthetic phospho-peptide corresponding to residues surrounding Ser345 of human phospho Chk1
Isotype	IgG1 Kappa
Modification	phospho-Ser345
Reactivity	Rat, Mouse, Human
Reregulatory	RUO

Clone No	Chk1S345-R3F9

Buffer	1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Concentration	0.5mg/ml
Dilutions	1.0 - 0.1 µg/ml
Storage	-20ºC

Applications	FACS
Description	FACS

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SKU	Supplier No.	Size	Your price	Quantity
BHA10600036	2191	200µl	$466.50		Add to Cart
BHA10600036	2191	20µl	$196.67		Add to Cart

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