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Home / Primary Antibodies / Phospho Antibodies

Anti-p38 MAPK Antibody (P38T180Y182-E3) FITC BHA10600089

SKU : BHA10600089

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Abwiz Bio Inc.

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Mfr.No.	1158
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	monoclonal
Description	p38 mitogen-activated protein kinase (MAPK) participates in a signaling cascade that controls cellular responses to stress signals and cytokines (1). p38 MAPK isoforms p38α, p38β, p38γ (also known as Erk6 or SAPK3), and p38δ (also known as SAPK4) have been identified. p38 MAPK activation signal include inflammatory cytokines, UV light, osmotic shock, lipopolysaccharide (LPS), and growth factors (1). MKK3, MKK6, and SEK all activate p38 MAPK by phosphorylation at Thr180 and Tyr182. phospho-p38 MAPK has been shown to phosphorylate and activate MAPKAPK-2 (2) and to phosphorylate the transcription factors ATF-2 and MEF2 (3). A selective inhibitor of phospho-p38 MAPK is SB203580 (4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-imidazole), which inhibits the MAPKAPK-2 activation by p38 MAPK and subsequent phosphorylation of HSP27 (4). SB203580 inhibits p38 MAPK catalytic activity by binding the ATP-binding pocket, but does not inhibit p38 MAPK phosphorylation by upstream kinases (5).
Host	Rabbit
Immunogen	A synthetic phospho-peptide corresponding to residues surrounding Thr180/Tyr182 of human phospho p38 MAPK.
Isotype	IgG1 Kappa
Modification	Phospho-Tyr182, Phospho-Thr180
Reactivity	Rat, Mouse, Human
Reregulatory	RUO

Clone No	P38T180Y182-E3

Buffer	1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Concentration	0.5mg/ml
Dilutions	1.0 - 0.1 µg/ml
Storage	-20ºC

Applications	FACS
Description	FACS

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SKU	Supplier No.	Size	Your price	Quantity
BHA10600089	1158	100Tests	$320.67		Add to Cart
BHA10600089	1158	10Tests	$120.67		Add to Cart

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