The TERC gene amplification probe uses orange-red to mark TERC gene region, and green dye to mark chromosome 3 centromeric region (CEP3). The TERC gene marker region is located at 3q26.2, and the CEP3 probe is marked by a specific alpha satellite sequence.
Description
Cervical cancer screening
Clinical Significance
The detection of TERC gene status in patients can help to distinguish between high and low precancerous cervical lesions and improve the sensitivity and specificity of cytology and HPV screening for cervical lesions. Aus-US/CIN1 and CIN2/CIN3 can be distinguished from the pathological grading by using a suitable treatment plan and detecting the TERC gene status. Predicting disease progression and early intervention, patients with TERC gene amplification have more than 50% chance of developing into high-level lesions.