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Home / Fish Probe

eFISH CHOP Dual Color Break Apart P

SKU : BHR15100134

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Mfr.No.	FP050-10X
Gene Name	CHOP
Fluorophore	Orange/Green
Chromosome	12
Intended Use	The BioGenex eFISH CHOP Dual Color Break Apart Probeis currently available forResearch use only.eFISH CHOP Dual Color Break Apart Probe is designed to detecttranslocation involving CHOPgene at 12q13in formalin-fixed, paraffin-embedded tissueor cells by fluorescence in situ hybridization (FISH).BioGenex eFISH CHOP Dual Color Break Apart Probe comes in hybridization buffer.The probe contains green-labeled polynucleotides (Green: excitation at 503 nm andemission at 528 nm, similar to FITC) which target sequences mappingin 12q13 distal tothe CHOP gene, and Orange labeled probes (Orange: excitation at 547 nm and emission at572 nm, similar to rhodamine), which target sequences mapping in12q13 proximal to theCHOP gene
Description	Fluorescence in situ hybridization (FISH) is a robust technique of cytogenetic used for thedetection of chromosomal aberrations, presence or absence of specific DNA sequence innative context. In this technique florescent probes bind to the target sequence of DNA inchromosome. High specificity and sensitivity coupled rapid and an accurate result hasproven role of FISH in both research and diagnosis of solid tumor and hematologicalmalignancies. As technique of cancer cytogenetics, FISH, can be used to identify geneticaberrations viz., deletions, amplification and translocation in tissue sections or within individual cells. FISH is also used for use in genetic counseling, medicine, and speciesidentification. FISH can also be used to detect and localize specific RNA targets in cells,circulating tumor cells, and tissue samples1,2,3,4,5.In FISH procedure, fixed tissue sections are pretreated to expose target DNA or mRNAsequences. An appropriately labeled probe is hybridized to the exposed target DNA ormRNA sequences in the cells. Subsequent stringent washing steps remove any probe thatis non-specifically bound to the tissue section. Subsequently slides are mounted usingDAPI/antifade and can be visualized under fluorescence microscope using appropriate filterset.
Principle	In Situ hybridization (ISH) allows the detection and localization of definitive nucleic acid sequences directly within a cell or tissue. High specificity is ensured through the action of annealing of fluorescence probe nucleic acid sequence to complementary target nucleic acid sequence. ISH techniques can be used to identify genetic aberrations like deletions, amplification, and translocationin tissue sections or within individual cells.
Storage	The eFISH CHOP Dual Color Break Apart Probe must be stored at 2-8°C protected from light and is stable through the expiry date printed on the label.

Reference	Datasheet SDS

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SKU	Supplier No.	Size	Your price	Quantity
BHR15100134	FP050-10X	10 tests	$1152		Add to Cart

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