The CCND1 gene amplification probe uses orange-red dye to mark CCND1(BCL1) region, and the green dye to mark the centromeric region of chromosome 11 (CEP 11 ). The CCND1 gene marker region is located in 11q13.3, and the CEP11 probe is labeled with a specific alpha satellite sequence.
Description
solid tumor
Clinical Significance
CCND1 gene amplification indicates that CCND1 gene plays an important role in tumor development. Patients with CCND1 gene amplification have poor prognosis and are closely related to chemotherapy resistance.