The ATM gene deletion probe is a dual color hybrid probe with a red fluorescent dye directly labeled ATM probe. The probe specifically acts on the ATM gene at the 11q22.3 of the chromosome region, and uses green fluorescent dyes to directly mark the centromere area of chromosome 11.
Description
Hematological tumor
Clinical Significance
The deletion of ATM gene in the B cell CLL has the incidence of 15-20%, which is associated with the invasion of the disease, and the prognosis is poor; the deletion of the ATM gene is the most common deletion in CLL, which can guide the choice of the treatment and the evaluation of the prognosis.