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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Ubiquitin-conjugating enzyme E2 B

SKU : BHE13811435

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1063r
Alternative Names	E2 ubiquitin-conjugating enzyme B ; RAD6 homolog B ; HR6B ; Ubiquitin carrier protein B ; Ubiquitin-conjugating enzyme E2(14k) ; Ubiquitin-protein ligase B ; Rad6b
Categories	Elisa
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
Specificity	Natural and recombinant Rat Ubiquitin-conjugating enzyme E2 B
Subcellular Location	Cell membrane Nucleus In peripheral neurons, expressed both at the plasma membrane and in nuclei.
Detection Range	0.312-20ng/mL
Entryname	UBE2B_RAT
Method Type	Sandwich
Platform	PF00179
Protein Name	Ubiquitin-conjugating enzyme E2 B
Sensitivity	0.186ng/mL
Sequence	50: MSTPARRRLM ; RDFKRLQEDP ; PVGVSGAPSE ; NNIMQWNAVI ; FGPEGTPFED ; 100: GTFKLVIEFS ; EEYPNKPPTV ; RFLSKMFHPN ; VYADGSICLD ; ILQNRWSPTY ; 150: DVSSILTSIQ ; SLLDEPNPNS ; PANSQAAQLY ; QENKREYEKR ; VSAIVEQSWN ; 152: DS
Sequence Length	152
String	P63149
Sub Unit	Interacts with RAD18, UBR2 and WAC.

Uniprot	P63149
Gene Name	Ube2b
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:81816
Unigene	Rn.20766

Reference	1. "A rabbit reticulocyte ubiquitin carrier protein that supports ubiquitin-dependent proteolysis (E214k) is homologous to the yeast DNA repair gene RAD6." Wing S.S., Dumas F., Banville D. J. Biol. Chem.267:6495-6501(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION 2. "14-kDa ubiquitin-conjugating enzyme: structure of the rat gene and regulation upon fasting and by insulin." Wing S.S., Banville D. Am. J. Physiol.267:E39-E48(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];TISSUE SPECIFICITY 3. "Isolation of a ubiquitin-conjugating enzyme gene induced following cerebral ischemia from the rat brain using modified subtractive hybridization and differential screening." Chen D., Graham S.H., Jing K., Simon R.P., Chen J. Submitted (1999-04) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE tissue: Brain. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Heart. 5. "The N-end rule ubiquitin-conjugating enzyme, HR6B, is up-regulated by nerve growth factor and required for neurite outgrowth." Kavakebi P., Hausott B., Tomasino A., Ingorokva S., Klimaschewski L. Mol. Cell. Neurosci.29:559-568(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;SUBCELLULAR LOCATION;FUNCTION

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811435	E1063r	96T	$796		Add to Cart

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