ELISA Kit for Rat Tyrosine-protein phosphatase non-receptor type 1

Mfr.No.	E1402r
Alternative Names	Protein-tyrosine phosphatase 1B ; PTP-1B
Categories	Elisa
Function	May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.
Specificity	Natural and recombinant Rat Tyrosine-protein phosphatase non-receptor type 1
Subcellular Location	Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side Interacts with EPHA3 at the cell membrane.
Detection Range	0.625-40ng/mL
Entryname	PTN1_RAT
Method Type	Sandwich
Platform	PF00102
Protein Name	Tyrosine-protein phosphatase non-receptor type 1
Sensitivity	0.312ng/mL
Sequence	50: MEMEKEFEQI ; DKAGNWAAIY ; QDIRHEASDF ; PCRIAKLPKN ; KNRNRYRDVS ; 100: PFDHSRIKLH ; QEDNDYINAS ; LIKMEEAQRS ; YILTQGPLPN ; TCGHFWEMVW ; 150: EQKSRGVVML ; NRIMEKGSLK ; CAQYWPQKEE ; KEMVFDDTNL ; KLTLISEDVK ; 200: SYYTVRQLEL ; ENLATQEARE ; ILHFHYTTWP ; DFGVPESPAS ; FLNFLFKVRE ; 250: SGSLSPEHGP ; IVVHCSAGIG ; RSGTFCLADT ; CLLLMDKRKD ; PSSVDIKKVL ; 300: LEMRRFRMGL ; IQTADQLRFS ; YLAVIEGAKF ; IMGDSSVQDQ ; WKELSHEDLE ; 350: PPPEHVPPPP ; RPPKRTLEPH ; NGKCKELFSN ; HQWVSEESCE ; DEDILAREES ; 400: RAPSIAVHSM ; SSMSQDTEVR ; KRMVGGGLQS ; AQASVPTEEE ; LSPTEEEQKA ; 432: HRPVHWKPFL ; VNVCMATALA ; TGAYLCYRVC ; FH
Sequence Length	432
String	P20417
Sub Unit	Interacts with EPHA3 (phosphorylated); dephosphorylates EPHA3 and may regulate its trafficking and function.

Reference	1. "Cloning and expression of a protein-tyrosine-phosphatase." Guan K., Haun R.S., Watson S.J., Geahlen R.L., Dixon J.E. Proc. Natl. Acad. Sci. U.S.A.87:1501-1505(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Testis. 3. "Insulin receptor and epidermal growth factor receptor dephosphorylation by three major rat liver protein-tyrosine phosphatases expressed in a recombinant bacterial system." Hashimoto N., Zhang W.R., Goldstein B.J. Biochem. J.284:569-576(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-283

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