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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Transcriptional coactivator YAP1

SKU : BHE13811907

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15210r
Alternative Names	Protein yorkie homolog ; Yes-associated protein YAP65 homolog ; Yap ; Yap65
Categories	Elisa
Function	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (By similarity). Isoform 2, isoform 3 and isoform 4 (lacking the C-terminal transactivation domain) can attenuate p73-mediated cell death signaling in transcriptional repression-induced atypical death (TRIAD) of neurons.
Specificity	Natural and recombinant Rat Transcriptional coactivator YAP1
Subcellular Location	Cytoplasm Nucleus Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density.
Entryname	YAP1_RAT
Platform	PF00397
Protein Name	Transcriptional coactivator YAP1
Sequence	50: MEPAQQPPPQ ; PAPQGPAPPS ; VSPAGTPAAP ; PAPPAGHQVV ; HVRGDSETDL ; 100: EALFNAVMNP ; KTANVPQTVP ; MRLRKLPDSF ; FKPPEPKSHS ; RQASTDAGTA ; 150: GALTPQHVRA ; HSSPASLQLG ; AGTLTASGVV ; SGPAATPAAQ ; HLRQSSFEIP ; 200: DDVPLPAGWE ; MAKTSSGQRY ; FLNHNDQTTT ; WQDPRKAMLS ; QLNVPTSASP ; 250: AVPQTLMNSA ; SGPLPDGWEQ ; AMTQDGEVYY ; INHKNKTTSW ; LDPRLDPRFA ; 300: MNQRITQSAP ; VKQPPPLAPQ ; SPQGGVLGGG ; SSNQQQQIQL ; QQLQMEKERL ; 350: RLKQQELFRQ ; ELALRSQLPS ; LEQDGGTQNA ; VSSPGMTQEL ; RTMTTNSSDP ; 400: FLNSGTYHSR ; DESTDSGLSM ; SSYSIPRTPD ; DFLNSVDEMD ; TGDTISQSTL ; 450: PSQQSRFPDY ; LEALPGTNVD ; LGTLEGDAMN ; IEGEELMPSL ; QEALSSEILD ; 469: VESVLAATKL ; DKESFLTWL
Sequence Length	469
String	Q2EJA0
Sub Unit	Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif. The phosphorylated form interacts with YWHAB. Interacts (via WW domains) with LATS1 (via PPxY motif 2). Interacts with LATS2. Interacts (via WW domain 1) with isoform 2 of ERBB4 (via PPxY motif 2). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4 (By similarity). Interacts with TP73 (By similarity). Interacts with RUNX1.

Uniprot	Q2EJA0
Gene Name	Yap1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:363014
Unigene	Rn.162978

Reference	1. "Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73." Hoshino M., Qi M.-L., Yoshimura N., Tagawa K., Wada Y.-I., Enokido Y., Marubuchi S., Harjes P., Arai N., Oyanagi K., Blandino G., Sudol M., Rich T., Kanazawa I., Wanker E.E., Saitoe M., Okazawa H. J. Cell Biol.172:589-604(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4);FUNCTION;INDUCTION;TISSUE SPECIFICITY strain: Wistar. 2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites." Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A. Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND THR-95;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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BHE13811907	E15210r	96T	$796		Add to Cart

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