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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Transcription factor Sp1

SKU : BHE13810953

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15093r
Categories	Elisa
Function	Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression (By similarity). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter.
Specificity	Natural and recombinant Rat Transcription factor Sp1
Subcellular Location	Nucleus Cytoplasm Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.
Detection Range	78-5000pg/mL
Entryname	SP1_RAT
Method Type	Sandwich
Platform	PF00096
Protein Name	Transcription factor Sp1
Sensitivity	39.4pg/mL
Sequence	50: MSDQDHSMDE ; VTAVKIEKGV ; GGNNGGSGNG ; GGAAFSQTRS ; SSTGSSSSSG ; 100: GGGGQESQPS ; PLALLAATCS ; RIESPNENSN ; NSQGPSQSGG ; TGELDLTATQ ; 150: LSQGANGWQI ; ISSSSGATPT ; SKEQSGNSTN ; GSNGSESSKN ; RTVSGGQYVV ; 200: AATPNLQNQQ ; VLTGLPGVMP ; NIQYQVIPQF ; QTVDGQQLQF ; AATGAQVQQD ; 250: GSGQIQIIPG ; ANQQIITNRG ; SGGNIIAAMP ; NLLQQAVPLQ ; GLANNVLSGQ ; 300: TQYVTNVPVA ; LNGNITLLPV ; NSVSAATLTP ; SSQAGTISSS ; GSQESGSQPV ; 350: TSGTAISSAS ; LVSSQASSSS ; FFTNANSYST ; TTTTSNMGIM ; NFTSSGSSGT ; 400: SSQGQTSQRV ; GGLQGSDSLN ; IQQNQTSGGS ; LQGSQQKEGE ; QSQQTQQQQI ; 450: LIQPQLVQGG ; QALQALQAAP ; LSGQTFTTQA ; ISQETLQNLQ ; LQAVQNSGPI ; 500: IIRTPTVGPN ; GQVSWQTLQL ; QNLQVQNPQA ; QTITLAPMQG ; VSLGQTSSSN ; 550: TTLTPIASAA ; SIPAGTVTVN ; AAQLSSMPGL ; QTINLSALGT ; SGIQVHQLPG ; 600: LPLAIANTPG ; DHGAQLGLHG ; PGGDGIHDET ; AGGEEGENSP ; DPQPQAGRRT ; 650: RREACTCPYC ; KDSEGRGSGD ; PGKKKQHICH ; IQGCGKVYGK ; TSHLRAHLRW ; 700: HTGERPFMCN ; WSYCGKRFTR ; SDELQRHKRT ; HTGEKKFACP ; ECPKRFMRSD ; 750: HLSKHIKTHQ ; NKKGGPGVAL ; SVGTLPLDSG ; AGSEGSGTAT ; PSALITTNMV ; 786: AMEAICPEGI ; ARLANSGINV ; MQVTELQSIN ; ISGNGF
Sequence Length	786
String	Q01714
Sub Unit	Interacts with ATF7IP, ATF7IP2, BAHD1, POGZ, HCFC1, AATF and PHC2. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the 2 proteins in DNA binding. Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts (deacetylated form) with EP300; the interaction enhances gene expression. Interacts with HDAC1 and JUN. Interacts with ELF1; the interaction is inhibited by glycosylation of SP1. Interaction with NFYA; the interaction is inhibited by glycosylation of SP1 (By similarity). Interacts with SMARCA4/BRG1. Interacts with ATF7IP and TBP(By similarity).

Uniprot	Q01714
Gene Name	Sp1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:24790
Unigene	Rn.44609

Reference	1. "Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene." Imataka H., Sogawa K., Yasumoto K., Kikuchi Y., Sasano K., Kobayashi A., Hayami M., Fujii-Kuriyama Y. EMBO J.11:3663-3671(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Liver. 2. "The trans-spliced variants of Sp1 mRNA in rat." Takahara T., Kasahara D., Mori D., Yanagisawa S., Akanuma H. Biochem. Biophys. Res. Commun.298:156-162(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-559;TISSUE SPECIFICITY tissue: Liver. 3. "A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression." Qiu Z., Ghosh A. Neuron60:775-787(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SMARCA4/BRG1

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810953	E15093r	96T	$796		Add to Cart

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