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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Transcription factor E2-alpha

SKU : BHE13810884

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14975r
Alternative Names	Immunoglobulin enhancer-binding factor E12/E47 ; Pancreas specific transcription factor 1c ; Transcription factor 3 ; TCF-3 ; Transcription regulator Pan ; Pan ; Ptf1c ; Tcfe2a
Categories	Elisa
Function	Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to the consensus sequence CAC/GCTGT/C present, in the chymotrypsin, insulin, AP-4, and several other gene enhancer motifs.
Specificity	Natural and recombinant Rat Transcription factor E2-alpha
Subcellular Location	Nucleus
Detection Range	78-5000pg/mL
Entryname	TFE2_RAT
Method Type	Sandwich
Platform	PF00010
Protein Name	Transcription factor E2-alpha
Sensitivity	27pg/mL
Sequence	50: MMNQSQRMAP ; VGSDKELSDL ; LDFSMMFPLP ; VANGKGRPAS ; LAGTQFAGSG ; 100: LEDRPSSESW ; GNSEQNSSSF ; DPSRAYSEGA ; HFSDSHSSLP ; PSTFLGAGLG ; 150: GKGSERNAYA ; TFGRDTSVGT ; LSQAGFLPGE ; LGLSSPGPLS ; PSGVKSSSQY ; 200: YTSFPSNPRR ; RAADGGLDTQ ; PKKVRKVPPG ; LPSSVYPSSS ; GDNYSRDATA ; 250: YPSAKTPSSA ; YPSPFYVADG ; SLHPSAELWS ; PPGQVGFGPM ; LGDGSAPLPL ; 300: APGSSSVSSG ; AFGGLQQQDR ; MGYQLHGSEV ; NGTLPAVSSF ; SAAPGTYSGT ; 350: SGHTPPVSGA ; DSLLGTRGTT ; ASSSGDALGK ; ALASIYSPDH ; SSNNFSPSPS ; 400: TPVGSPQGLP ; GTSQWPRAGA ; PSALSPNYDA ; GLHGLSKMED ; RLDEAIHVLR ; 450: SHAVGTASEL ; HGLLPGHSTL ; TTSFAGPMSL ; GGRHAGLVSG ; SHPEDGLTSG ; 500: ASLLHNHASL ; PSQPSSLPDL ; SQRPPDSFSG ; LGRAGVTAGA ; SEIKREEKED ; 550: EEVTSVADAE ; EDKKDLKVPR ; TRTSPDEDED ; DLLPPEQKAE ; REKERRVANN ; 600: ARERLRVRDI ; NEAFKELGRM ; CQLHLSTEKP ; QTKLLILHQA ; VAVILSLEQQ ; 649: VRERNLNPKA ; ACLKRREEEK ; VSGVVGDPQL ; ALSAAHPGLG ; EAHNPAGHL
Sequence Length	649
String	P21677
Sub Unit	Homodimer. Heterodimer. Forms a heterodimer with ASH1 and TWIST2. Forms a heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element. Isoform E12 interacts with RALGAPA1 and FIGLA. Interacts with EP300, NEUROD2, PTF1A and TGFB1I1. Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Efficient DNA binding requires dimerization with another bHLH protein (By similarity). Interacts with UBE2I.

Uniprot	P21677
Gene Name	Tcf3
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:171046
Unigene	Rn.10290

Reference	1. "Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs." Nelson C., Shen L.-P., Meister A., Fodor E., Rutter W.J. Genes Dev.4:1035-1043(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS E12 AND E47) 2. Wellauer P.K. Submitted (2005-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM E12) strain: Sprague-Dawley. 3. "The helix-loop-helix protein rE12 and the C/EBP-related factor rNFIL-6 bind to neighboring sites within the c-fos serum response element." Metz R., Ziff E. Oncogene6:2165-2178(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 427-649 (ISOFORM E12) 4. "Degradation of E2A proteins through a ubiquitin-conjugating enzyme, UbcE2A." Kho C.-J., Huggins G.S., Endege W.O., Hsieh C.-M., Lee M.-E., Haber E. J. Biol. Chem.272:3845-3851(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBE2I strain: CD Charles River. tissue: Aorta.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810884	E14975r	96T	$796		Add to Cart

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