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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Telomerase reverse transcriptase

SKU : BHE13810876

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2133r
Alternative Names	Telomerase catalytic subunit
Categories	Elisa
Function	Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
Specificity	Natural and recombinant Rat Telomerase reverse transcriptase
Subcellular Location	Nucleus nucleolus Nucleus nucleoplasm Nucleus Chromosome telomere Cytoplasm Nucleus PML body Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress-mediated phosphorylation at Tyr-697. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT.
Detection Range	0.78-50ng/mL
Entryname	TERT_RAT
Method Type	Sandwich
Platform	PF00078
Protein Name	Telomerase reverse transcriptase
Sensitivity	0.24ng/mL
Sequence	50: MPRAPRCPAV ; RSLLRSRYRE ; VWPLATFVRR ; LGLEGSRLVQ ; PGDPKVFRTL ; 100: VAQCLVCVPW ; GSQPPPADLS ; FHQVSSLKEL ; VSRVVQKLCE ; RGERNVLAFG ; 150: FALLNGARGG ; PPMAFTTSVH ; SYLPNSVTES ; LCVSGAWMLL ; LSRVGDDLLV ; 200: YLLSHCALYL ; LVPPSCAYQV ; CGSPLYQICA ; TTDTWSSVPA ; GYRPTRPVGG ; 250: NFTNLGSAHQ ; IKNSGHQEAP ; KPQALPSRGT ; KRLLSLTSTN ; VPSAKKARFE ; 300: PALRVDKGPH ; RQVVPTPSGK ; TWAPSPAASP ; KVPPAAKNLS ; LKGKASDPSL ; 350: SGSVCCKHKP ; SSSSLLSSPP ; QDAEKLRPFT ; ETRHFLYSRG ; GGQEELNPSF ; 400: LLNSLPPSLT ; GARRLVEIIF ; LGSRPRTSGP ; FCRTRRLPRR ; YWQMRPLFQQ ; 450: LLMNHAKCQY ; VRFLRSHCRF ; RTANQRVPDA ; MDTSPSHLTS ; LLRLHSSPWQ ; 500: VYGFLRACLR ; ELVPAGLWGT ; RHNERRFLKN ; VKKFISLGKY ; AKLSLQELMW ; 550: RVKVEDCHWL ; RSSPEKDTVP ; AAEHRLRERI ; LAMFLFWLMD ; TYVVQLLRSF ; 600: FYITETTFQK ; NRLFFYRKSV ; WSKLQSIGIR ; QQLERVQLRE ; LSQEEVKHHQ ; 650: DTWLAMPICR ; LRFIPKLNGL ; RPIVNMSYGM ; DTRAFGKKKQ ; TQCFTQSLKT ; 700: LFSVLNYERT ; KHPNLMGASV ; LGTSDSYRIW ; RTFVLRVRAL ; DQTPRMYFVK ; 750: ADVTGAYDAI ; PQDKLVEIVA ; NIIRRSESMY ; CIRQYAVVQK ; DSQGQVHKSF ; 800: RRQVSTLSDL ; QPYMGQFTKH ; LQDSDASALR ; NSVVIEQSIS ; MNETGSSLLH ; 850: FFLRFVRHSV ; VKIDGRFYVQ ; CQGIPQGSSL ; STLLCSLCFG ; DMENKLFAEV ; 900: QQDGLLLRFV ; DDFLLVTPHL ; AHAKAFLSTL ; VHGVPEYGCM ; INLQKTVVNF ; 950: PVETGALGGA ; APHQLPAHCL ; FPWCGLLLDT ; RTLEVFCDYS ; GYGRTSIKMS ; 1000: LTFQGVSRAG ; KTMRYKLLSV ; LRLKCHGLFL ; DLQVNSLQTV ; CINIYKIFLL ; 1050: QAYRFHACVI ; RLPFGQHVRK ; NHAFFLGIIS ; NLASCCYAIL ; KVKNPGVSLR ; 1100: AKGAPGSFPP ; EATRWLCYQA ; FLLKLAAHSV ; TYKCLLGPLR ; TAQKQLCRKL ; 1125: PEATMTLLKT ; AADPALSTDF ; QTILD
Sequence Length	1125
String	Q673L6
Sub Unit	Homodimer; dimerization is required to produce a functional complex. Oligomer; can form oligomers in the absence of the telomerase RNA template component (TERC). Catalytic subunit of the telomerase holoenzyme complex composed minimally of TERT and TERC. The telomerase complex is composed of TERT, DKC1, WDR79/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). The molecular chaperone HSP90/P23 complex is required for correct assembly and stabilization of the active telomerase. Interacts directly with HSP90A and PTGES3. Interacts with HSPA1A; the interaction occurs in the absence of TERC and dissociates once the complex has formed. Interacts with RAN; the interaction promotes nuclear export of TERT. Interacts with XPO1. Interacts with PTPN11; the interaction retains TERT in the nucleus. Interacts with NCL (via RRM1 and C-terminal RRM4/Arg/Gly-rich domains); the interaction is important for nucleolar localization of TERT. Interacts with SMARCA4 (via the bromodomain); the interaction regulates Wnt-mediated signaling (By similarity). Interacts with MCRS1 (isoform MCRS2); the interaction inhibits in vitro telomerase activity. Interacts with PIF1; the interaction has no effect on the elongation activity of TERT. Interacts with PML; the interaction recruits TERT to PML bodies and inhibits telomerase activity.

Uniprot	Q673L6
Gene Name	Tert
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:301965
Unigene	Rn.48802

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810876	E2133r	96T	$796		Add to Cart

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