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ELISA Kit for Rat Telomerase protein component 1

SKU : BHE13810889

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0558r
Alternative Names	Telomerase-associated protein 1 ; Telomerase protein 1 ; p230 ; p240 ; p80 telomerase homolog ; Tlp1
Categories	Elisa
Function	Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC.
Specificity	Natural and recombinant Rat Telomerase protein component 1
Subcellular Location	Nucleus Chromosome telomere
Detection Range	31.2-2000pg/mL
Entryname	TEP1_RAT
Method Type	Sandwich
Platform	PF13271
Protein Name	Telomerase protein component 1
Sensitivity	14.6pg/mL
Sequence	50: MEKLCGYVPV ; HPDILSLKNR ; CLTMLSDIQP ; LEKIHGQRSV ; NPDILSLENR ; 100: CLTLLPDLQP ; MEKIHGQRSV ; HPDILSSENR ; CLTLLPDLQS ; LEKLCGHMSS ; 150: HPDVLSLENR ; CLATLPTVKR ; TVSSGPLLQC ; LHRSHTAQAD ; LRDPNFRNCL ; 200: FPEPPTIEAP ; CFLKELDLPT ; GPRALKSMSA ; TARVQEVALG ; QRCVSEGKEL ; 250: QEEKESAEVP ; MPLYSLSLGG ; EEEEVVGAPV ; LKLTSGDSDS ; HPETTDQILQ ; 300: EKKMALLTLL ; CSAMASSVNV ; KDASDPTRAS ; IHEVCSALAP ; LEPEFILKAS ; 350: LYARQQLNLR ; DIANIVLAVA ; ALLPACRPHV ; RRYYSAIVHL ; PSDWIQVAEF ; 400: YQSLAEGDEK ; KLVPLPACLR ; AAMTDKFAQF ; DEYQLAKYNP ; RKHRSKTRSR ; 450: QPPRPQRTKP ; PFSESGKCFP ; KSVWPLKNEQ ; ISFEAAYNAV ; SEKKRLPRFT ; 500: LKKLVEQLHI ; HEPAQHVQAL ; LGYRYPSTLE ; LFSRSHLPGP ; WDSSRAGQRM ; 550: KLQRPETWER ; ELSLRGNRAS ; VWEELIDNGK ; LPFMAMLRNL ; CNLLRTGISA ; 600: HHHELVLQRL ; QHEKSVIHSR ; QFPFRFLNAH ; DSLDRLEAQL ; RSKASPFPSN ; 650: TTLMKRIMIR ; NSKKIKRPAN ; PRYLCTLTQR ; QLRAAMAIPV ; MYEHLKREKL ; 700: RLHKARQWTC ; DLELLERYRQ ; ALETAVNISV ; KHNLPPLPGR ; TLLVYLTDAN ; 750: ANRLCPKSHL ; QGPPLNYVLL ; LIGMMMARAE ; QTTVWLCGTG ; TVKTPVLTAD ; 800: EGILKTAIKL ; QAQVQELEEN ; DEWPLETFEK ; YLLSLAVRRT ; PIDRVILFGQ ; 850: RMDTELLNVA ; KQIIWQHVNS ; KCLFVSVLLR ; KMQYMSPNLN ; PNDVTLSGCT ; 900: DGILKFIAEH ; GASRLLEHVG ; QLDKIFKIPP ; PPGKTKVSPL ; RPLEENNPGP ; 950: FVPISQHGWR ; NIRLFISSTF ; RDMHGERDLL ; MRSVLPALQA ; RAFPHRISLH ; 1000: AIDLRWGITE ; EETRRNRQLE ; VCLGEVENSQ ; LFVGILGSRY ; GYTPPSYDLP ; 1050: DHPHFHWTQR ; YPSGRSVTEM ; EVMQFLNRGQ ; RSEPSDQALI ; YFRDPGFLSS ; 1100: VPDVWKPDFI ; SESEEAAHRV ; SELKRFLQEQ ; KEVTCRRYSC ; EWGGVAAGRP ; 1150: YTGGLEEFGQ ; LVLQDVWSVI ; QKRYLQPGAQ ; LEQPGSISEE ; DLIQASFQQL ; 1200: KSPPSPARPR ; LLQDTVQQLM ; LPHGRLSLVI ; GQAGQGKTAF ; LASLVSALKV ; 1250: PDQPNVAPFV ; FFHFSAARPD ; QCLAFNLLRR ; LCTHLHQKLG ; EPSALPSTYR ; 1300: GLVWELQQKL ; LLKSAQWLQP ; GQTLVLIIDG ; ADKLVDHNGQ ; LISDWIPKSL ; 1350: PRRVHLVLSV ; SSDSGLGETL ; QQSQSAYVVA ; LGSLVPSSRA ; QLVREELALY ; 1400: GKRLEESPFN ; NQMRLLLAKQ ; GSSLPLYLHL ; VTDYLRLFTL ; YEQVSERLRT ; 1450: LPATLPLLLQ ; HILSTLEQEH ; GHNVLPQALT ; ALEVTHSGLT ; VDQLHAVLST ; 1500: WLTLPKETKS ; WEEAVAASHS ; GNLYPLAPFA ; YLVQSLRSLL ; GEGPVERPGA ; 1550: RLCLSDGPLR ; TAVKRRYGKR ; LGLEKTAHVL ; IAAHLWKMCD ; PDASGTFRSC ; 1600: PPEALKDLPY ; HLLQSGNHGL ; LAKFLTNLHV ; VAAYLEVGLV ; PDLLEAYELY ; 1650: ASSKPEVNQK ; LPEADVAVFH ; NFLKQQASLL ; TQYPLLLLQQ ; AASQPEESPV ; 1700: CCQAPLLTQR ; WHNQCILKWI ; NKPQTLKGQQ ; SLSLPISSSP ; TAVAFSPNGQ ; 1750: RAAVGTAGGT ; IYLLNLRTWQ ; EEKALVSGCD ; GISSFAFLSD ; TALFLTTFDG ; 1800: LLELWDLQHG ; CWVFQTKAHQ ; YQITGCCLSP ; DRRLLATVCL ; GGYVKLWDTV ; 1850: QGQLAFQYTH ; PKSLNCITFH ; PEGQVVATGN ; WSGIVTFFQA ; DGLKVTKELG ; 1900: GPGPSVRTLA ; FSAPGKVVAL ; GRIDGTVELW ; AWQEGTRLAA ; FPAQCGGVST ; 1950: VLFLHAGGRF ; LTAGEDGKAQ ; LWSGFLGRPR ; GCLGSLYLSP ; ALSVALNPDG ; 2000: DQVAVGYRGD ; GIKIYRISSG ; PQEAQCQELN ; VAVSALVWLS ; PSVLVSGAED ; 2050: GSLHGWMLRR ; NSLQSLWLSS ; VCQKPVLGLA ; ASQEFLASAS ; EDFTVRLWPR ; 2100: QLLTQPHAVE ; ELPCAAELRG ; HEGPVCCCSF ; SPDGRILATA ; GRDRNLLCWD ; 2150: VKVAQAPLLI ; HTFSSCHRDW ; ITGCTWTKDN ; ILISCSSDGS ; VGLWNPEAGQ ; 2200: QLGQFPGHQS ; AVSAVVAVEE ; HIVSVSRDGT ; LKVWDRQGVE ; LTSIPAHSGP ; 2250: ISQCAAALEP ; RPAGQPGSEL ; MVVTVGLDGA ; TKLWHPLLVC ; QIHTLQGHSG ; 2300: PVTAAAASEA ; SGLLLTSDNS ; SVRLWQIPKE ; ADDTCKPRSS ; AVITAVAWAP ; 2350: DGSLVVSGNE ; AGELTLWQKA ; QAVATARAPG ; RVSDLIWCSA ; NAFFVLSANE ; 2400: NVSEWQVELR ; KGSTCTNFRL ; YLKRVLQEDL ; GVLTGMALAP ; DGQSLILMKE ; 2450: DVELLQMKPG ; STPSSICRRY ; AVHSSILCTS ; KDYGLFYLQQ ; GNSGSLSILE ; 2500: QEESGKFEKT ; LDFNLNLNNP ; NGSPVSITQA ; EPESGSSLLC ; ATSDGMLWNL ; 2550: SECTPEGEWV ; VDNIWQKKSR ; NPKSRTPGTD ; SSPGLFCMDS ; WVEPTHLKAR ; 2600: QCKKIHLGSV ; TALHVLPGLL ; VTASEDRDVK ; LWERPSMQLL ; GLFRCEGPVS ; 2629: CLEPWMEPSS ; PLQLAVGDAQ ; GNLYFLSWE
Sequence Length	2629
String	O08653
Sub Unit	Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs.

Uniprot	O08653
Gene Name	Tep1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:64523
Unigene	Rn.5890

Reference	1. "TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family." Nakayama J., Saito M., Nakamura H., Matsuura A., Ishikawa F. Cell88:875-884(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX strain: Fischer 344. tissue: Fibroblast. 2. "Vaults and telomerase share a common subunit, TEP1." Kickhoefer V.A., Stephen A.G., Harrington L., Robinson M.O., Rome L.H. J. Biol. Chem.274:32712-32717(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE VAULTS RIBONUCLEOPROTEIN PARTICLE 3. "RNA location and modeling of a WD40 repeat domain within the vault." Kong L.B., Siva A.C., Kickhoefer V.A., Rome L.H., Stewart P.L. RNA6:890-900(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ELECTRON CRYOMICROSCOPY (22 ANGSTROMS) OF VAULT COMPLEX AND TEP1 WD REPEATS MODELING

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