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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Suppressor of cytokine signaling 3

SKU : BHE13809316

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1684r
Alternative Names	Cytokine-inducible SH2 protein 3 ; Cish3
Categories	Elisa
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.
Specificity	Natural and recombinant Rat Suppressor of cytokine signaling 3
Detection Range	78-5000pg/mL
Entryname	SOCS3_RAT
Method Type	Sandwich
Platform	PF00017
Protein Name	Suppressor of cytokine signaling 3
Sensitivity	39pg/mL
Sequence	50: MVTHSKFPAA ; GMSRPLDTSL ; RLKTFSSKSE ; YQLVVNAVRK ; LQESGFYWSA ; 100: VTGGEANLLL ; SAEPAGTFLI ; RDSSDQRHFF ; TLSVETQSGT ; KNLRIQCEGG ; 150: SFSLQSDPRS ; TQPVPRFDCV ; LKLVHHYMPP ; PGAPSFSLPP ; TEPSFEVQEQ ; 200: PPAQALPGGT ; PKRAYYIYSG ; GEKIPLVLSR ; PLSSNVATLQ ; HLCRKTVNGH ; 225: LDSYEKVTQL ; PGPIREFLDQ ; YDAPL
Sequence Length	225
String	O88583
Sub Unit	Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors. Interaction with CSNK1E stabilize SOCS3 protein. Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SOCS3. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with FGFR3.

Uniprot	O88583
Gene Name	Socs3
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:89829
Unigene	Rn.127801

Reference	1. "Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo." Mao Y., Ling P.R., Fitzgibbons T.P., McCowen K.C., Frick G.P., Bistrian B.R., Smith R.J. Endocrinology140:5505-5515(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Liver. 2. le Cam A. Submitted (1999-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] strain: Sprague-Dawley. 3. "Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor." Eyckerman S., Broekaert D., Verhee A., Vandekerckhove J., Tavernier J. FEBS Lett.486:33-37(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LEPTIN

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809316	E1684r	96T	$796		Add to Cart

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