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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Suppressor of cytokine signaling 1

SKU : BHE13810898

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1416r
Categories	Elisa
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2.
Specificity	Natural and recombinant Rat Suppressor of cytokine signaling 1
Subcellular Location	Nucleus Cytoplasmic vesicle Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
Detection Range	0.312-20ng/mL
Entryname	SOCS1_RAT
Method Type	Sandwich
Platform	PF00017
Protein Name	Suppressor of cytokine signaling 1
Sensitivity	0.164ng/mL
Sequence	50: MVARNQVAAD ; NAISPASEPR ; RRPEPSSSSS ; SSSPAAPRRP ; RPCPVVPAPA ; 100: PGDTHFRTFR ; SHSDYRRITR ; TSALLDACGF ; YWGPLSVHGA ; HERLRAEPVG ; 150: TFLVRDSRQR ; NCFFALSVKM ; ASGPTSIRVH ; FQAGRFHLDG ; SRETFDCLFE ; 200: LLEHYVAAPR ; RMLGAPLRQR ; RVRPLQELCR ; QRIVAAVGRE ; NLARIPLNPV ; 212: LRDYLSSFPF ; QI
Sequence Length	212
String	Q9QX78
Sub Unit	Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV (By similarity). Binding to JAKs is mediated through the KIR and SH2 domain to a phosphorylated tyrosine residue within the JAK JH1 domain (By similarity). Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV (By similarity). Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1. Interacts (via SH2 domain and SOCS box) with TRIM8 (By similarity). Interacts with CUL2. Interacts with AXL and FGFR3.

Uniprot	Q9QX78
Gene Name	Socs1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:252971
Unigene	Rn.82754

Reference	1. le Cam A. Submitted (1999-06) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] strain: Sprague-Dawley.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810898	E1416r	96T	$796		Add to Cart

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