ELISA Kit for Rat Sorbin and SH3 domain-containing protein 1

Mfr.No.	E3361r
Alternative Names	Ponsin ; SH3P12
Categories	Elisa
Function	Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.
Specificity	Natural and recombinant Rat Sorbin and SH3 domain-containing protein 1
Subcellular Location	Cell junction adherens junction Cell membrane Cytoplasm cytoskeleton Cell junction focal adhesion Colocalized with PXN at focal adhesions during myogenic differentiation (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions.
Detection Range	0.625-40ng/mL
Entryname	SRBS1_RAT
Method Type	Sandwich
Protein Name	Sorbin and SH3 domain-containing protein 1
Sensitivity	0.333ng/mL
Sequence	35: LNRDDDSDLH ; SPRYSFSEDT ; KCDDGWFVGT ; SRRTK
Sequence Length	35
String	P84109
Sub Unit	Interacts with the long isoform of MLLT4/afadin and with VCL. MLLT4 and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex. Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1. Interacts with the insulin receptor but dissociates from it following insulin stimulation. Also interacts with SCA7, PTK2/p125FAK and flotillin. Interacts (via SH3 domain 2) with PXN.

Reference	1. "Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions." Mandai K., Nakanishi H., Satoh A., Takahashi K., Satoh K., Nishioka H., Mizoguchi A., Takai Y. J. Cell Biol.144:1001-1017(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE;SUBCELLULAR LOCATION tissue: Liver.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810779	E3361r	96T	$796		Add to Cart