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ELISA Kit for Rat Sodium-dependent serotonin transporter

SKU : BHE13809797

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2290r
Alternative Names	5HT transporter ; 5HTT ; Solute carrier family 6 member 4
Categories	Elisa
Function	Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Specificity	Natural and recombinant Rat Sodium-dependent serotonin transporter
Subcellular Location	Cell membrane Multi-pass membrane protein Endomembrane system Multi-pass membrane protein Endosome membrane Multi-pass membrane protein Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin. function as homooligomeric forms.
Detection Range	0.156-10ng/mL
Entryname	SC6A4_RAT
Method Type	Sandwich
Platform	PF03491
Protein Name	Sodium-dependent serotonin transporter
Sensitivity	0.09ng/mL
Sequence	50: METTPLNSQK ; VLSECKDRED ; CQENGVLQKG ; VPTTADRAEP ; SQISNGYSAV ; 100: PSTSAGDEAS ; HSIPAATTTL ; VAEIRQGERE ; TWGKKMDFLL ; SVIGYAVDLG ; 150: NIWRFPYICY ; QNGGGAFLLP ; YTIMAIFGGI ; PLFYMELALG ; QYHRNGCISI ; 200: WRKICPIFKG ; IGYAICIIAF ; YIASYYNTII ; AWALYYLISS ; LTDRLPWTSC ; 250: TNSWNTGNCT ; NYFAQDNITW ; TLHSTSPAEE ; FYLRHVLQIH ; QSKGLQDLGT ; 300: ISWQLTLCIV ; LIFTVIYFSI ; WKGVKTSGKV ; VWVTATFPYI ; VLSVLLVRGA ; 350: TLPGAWRGVV ; FYLKPNWQKL ; LETGVWVDAA ; AQIFFSLGPG ; FGVLLAFASY ; 400: NKFNNNCYQD ; ALVTSVVNCM ; TSFVSGFVIF ; TVLGYMAEMR ; NEDVSEVAKD ; 450: AGPSLLFITY ; AEAIANMPAS ; TFFAIIFFLM ; LITLGLDSTF ; AGLEGVITAV ; 500: LDEFPHIWAK ; RREWFVLIVV ; ITCVLGSLLT ; LTSGGAYVVT ; LLEEYATGPA ; 550: VLTVALIEAV ; AVSWFYGITQ ; FCSDVKEMLG ; FSPGWFWRIC ; WVAISPLFLL ; 600: FIICSFLMSP ; PQLRLFQYNY ; PHWSIVLGYC ; IGMSSVICIP ; TYIIYRLIST ; 630: PGTLKERIIK ; SITPETPTEI ; PCGDIRMNAV ;
Sequence Length	630
String	P31652
Sub Unit	Monomer or homooligomer. Interacts with TGFB1I1. Interacts (via C-terminus) with VIM. Interacts with RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly. Interacts with SEC23A, SEC24C and INADL. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake (By similarity). Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with filamentous actin and STX1A. Interacts (via sialylated form) with MYH9.

Uniprot	P31652
Gene Name	Slc6a4
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:25553
Unigene	Rn.1663

Reference	1. "Isolation of cDNAs encoding a novel member of the neurotransmitter transporter gene family." Mayser W., Betz H., Schloss P. FEBS Lett.295:203-206(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Wistar. 2. "Cloning and expression of a functional serotonin transporter from rat brain." Blakely R.D., Berson H.E., Fremeau R.T. Jr., Caron M.G., Peek M.M., Prince H.K., Bardley C.C. Nature354:66-70(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain stem. 3. Blakely R.D. Submitted (1992-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION 4. "Cloning of a serotonin transporter affected by antidepressants." Hoffman B.J., Mezey E., Brownstein M.J. Science254:579-580(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 5. Gonzalez A.M., Smith A.P.L., Emery C.J., Higenbottam T.W. Submitted (1997-02) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Fawn hooded. 6. "Oligomerization of serotonin transporter and its functional consequences." Kilic F., Rudnick G. Proc. Natl. Acad. Sci. U.S.A.97:3106-3111(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-109 AND ILE-172;SUBUNIT;SUBCELLULAR LOCATION 7. "Regulation of the serotonin transporter by interacting proteins." Haase J., Killian A.M., Magnani F., Williams C. Biochem. Soc. Trans.29:722-728(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STX1A;SUBCELLULAR LOCATION 8. "Glycosyl modification facilitates homo- and hetero-oligomerization of the serotonin transporter. A specific role for sialic acid residues." Ozaslan D., Wang S., Ahmed B.A., Kocabas A.M., McCastlain J.C., Bene A., Kilic F. J. Biol. Chem.278:43991-44000(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;MUTAGENESIS OF ASN-208 AND ASN-217;SUBUNIT;INTERACTION WITH MYH9 9. "Role of C-terminal region in the functional regulation of rat serotonin transporter (SERT)." Mochizuki H., Amano T., Seki T., Matsubayashi H., Mitsuhata C., Morita K., Kitayama S., Dohi T., Mishima H.K., Sakai N. Neurochem. Int.46:93-105(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH FILAMENTOUS ACTIN 10. "Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2." Mueller H.K., Wiborg O., Haase J. J. Biol. Chem.281:28901-28909(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SCAMP2;SUBCELLULAR LOCATION 11. "Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP." Ramamoorthy S., Samuvel D.J., Buck E.R., Rudnick G., Jayanthi L.D. J. Biol. Chem.282:11639-11647(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-276

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