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ELISA Kit for Rat Sigma non-opioid intracellular receptor 1

SKU : BHE13809732

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E5642r
Alternative Names	Sigma 1-type opioid receptor ; Sigma1-receptor ; Oprs1
Categories	Elisa
Function	Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.
Specificity	Natural and recombinant Rat Sigma non-opioid intracellular receptor 1
Subcellular Location	Nucleus inner membrane Nucleus outer membrane Endoplasmic reticulum membrane Lipid droplet Cell junction Cell membrane Cell projection growth cone Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding.
Entryname	SGMR1_RAT
Platform	PF04622
Protein Name	Sigma non-opioid intracellular receptor 1
Sequence	50: MPWAVGRRWA ; WITLFLTIVA ; VLIQAVWLWL ; GTQSFVFQRE ; EIAQLARQYA ; 100: GLDHELAFSR ; LIVELRRLHP ; GHVLPDEELQ ; WVFVNAGGWM ; GAMCLLHASL ; 150: SEYVLLFGTA ; LGSHGHSGRY ; WAEISDTIIS ; GTFHQWREGT ; TKSEVYYPGE ; 200: TVVHGPGEAT ; AVEWGPNTWM ; VEYGRGVIPS ; TLAFALSDTI ; FSTQDFLTLF ; 223: YTLRAYARGL ; RLELTTYLFG ; QDP
Sequence Length	223
String	Q9R0C9
Sub Unit	Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists. Interacts with KCNA4.

Uniprot	Q9R0C9
Gene Name	Sigmar1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:29336
Unigene	Rn.1129

Reference	1. "Cloning and functional characterization of a sigma receptor from rat brain." Seth P., Fei Y.-J., Li H.W., Huang W., Leibach F.H., Ganapathy V. J. Neurochem.70:922-931(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY strain: Sprague-Dawley. tissue: Brain. 2. "Sigma1 receptor modulation of opioid analgesia in the mouse." Mei J., Pasternak G.W. J. Pharmacol. Exp. Ther.300:1070-1074(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION tissue: Brain. 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) tissue: Prostate. 4. "Immunocytochemical localization of the sigma(1) receptor in the adult rat central nervous system." Alonso G., Phan V.-L., Guillemain I., Saunier M., Legrand A., Anoal M., Maurice T. Neuroscience97:155-170(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION 5. "Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina." Ola M.S., Moore P., El-Sherbeny A., Roon P., Agarwal N., Sarthy V.P., Casellas P., Ganapathy V., Smith S.B. Brain Res. Mol. Brain Res.95:86-95(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY 6. "Regulating ankyrin dynamics: roles of sigma-1 receptors." Hayashi T., Su T.-P. Proc. Natl. Acad. Sci. U.S.A.98:491-496(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ANK2 AND ITPR3;SUBCELLULAR LOCATION 7. "The sigma receptor as a ligand-regulated auxiliary potassium channel subunit." Aydar E., Palmer C.P., Klyachko V.A., Jackson M.B. Neuron34:399-410(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TOPOLOGY;SUBCELLULAR LOCATION;INTERACTION WITH KCNA4 8. "Immunohistochemical localization of the sigma1-receptor in oligodendrocytes in the rat central nervous system." Palacios G., Muro A., Vela J.M., Molina-Holgado E., Guitart X., Ovalle S., Zamanillo D. Brain Res.961:92-99(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY 9. "Immunohistochemical localization of the sigma1 receptor in Schwann cells of rat sciatic nerve." Palacios G., Muro A., Verdu E., Pumarola M., Vela J.M. Brain Res.1007:65-70(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY 10. "Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation." Hayashi T., Su T.-P. Proc. Natl. Acad. Sci. U.S.A.101:14949-14954(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION 11. "Sigma-1 receptors potentiate epidermal growth factor signaling towards neuritogenesis in PC12 cells: potential relation to lipid raft reconstitution." Takebayashi M., Hayashi T., Su T.-P. Synapse53:90-103(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 12. "Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release." Yagasaki Y., Numakawa T., Kumamaru E., Hayashi T., Su T.-P., Kunugi H. J. Biol. Chem.281:12941-12949(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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