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ELISA Kit for Rat Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

SKU : BHE13809245

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9568r
Alternative Names	Ppp1a
Categories	Elisa
Function	Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage.
Specificity	Natural and recombinant Rat Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Subcellular Location	Cytoplasm Nucleus Nucleus nucleoplasm Nucleus nucleolus Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting it to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
Detection Range	0.312-20ng/mL
Entryname	PP1A_RAT
Method Type	Sandwich
Platform	PF00149
Protein Name	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Sensitivity	0.171ng/mL
Sequence	50: MSDSEKLNLD ; SIIGRLLEVQ ; GSRPGKNVQL ; TENEIRGLCL ; KSREIFLSQP ; 100: ILLELEAPLK ; ICGDIHGQYY ; DLLRLFEYGG ; FPPESNYLFL ; GDYVDRGKQS ; 150: LETICLLLAY ; KIKYPENFFL ; LRGNHECASI ; NRIYGFYDEC ; KRRYNIKLWK ; 200: TFTDCFNCLP ; IAAIVDEKIF ; CCHGGLSPDL ; QSMEQIRRIM ; RPTDVPDQGL ; 250: LCDLLWSDPD ; KDVQGWGEND ; RGVSFTFGAE ; VVAKFLHKHD ; LDLICRAHQV ; 300: VEDGYEFFAK ; RQLVTLFSAP ; NYCGEFDNAG ; AMMSVDETLM ; CSFQILKPAD ; 330: KNKGKYGQFS ; GLNPGGRPIT ; PPRNSAKAKK ;
Sequence Length	330
String	P62138
Sub Unit	PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Interacts with PPP1R15A and PPP1R15B; the interactions mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with PPP1R7. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5. Interacts with NOM1 and PPP1R8. Interacts with PPP1R16B. Interacts with RPSA only in the presence of PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS and PPP1R8. Interacts with WDR82 in the presence of PPP1R10/PNUTS. Interacts with SH3RF2. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on 'Ser-824' and forms a complex at the p21 promoter site (By similarity). Interacts with PPP1R9A, PPP1R9B and YLPM1. Interacts with NEK2.

Uniprot	P62138
Gene Name	Ppp1ca
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:24668
Unigene	Rn.2024

Reference	1. "Molecular cloning and sequence analysis of cDNA for the catalytic subunit 1 alpha of rat kidney type 1 protein phosphatase, and detection of the gene expression at high levels in hepatoma cells and regenerating livers as compared to rat livers." Kitamura K., Mizuno Y., Sasaki A., Yasui A., Tsuiki S., Kikuchi K. J. Biochem.109:307-310(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Kidney. 2. "Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas." Sasaki K., Shima H., Kitagawa Y., Irino S., Sugimura T., Nagao M. Jpn. J. Cancer Res.81:1272-1280(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "Differential expression of protein phosphatase 1 isoforms in mammalian brain." da Cruz e Silva E.F., Fox C.A., Ouimet C.C., Gustafson E., Watson S.J., Greengard P. J. Neurosci.15:3375-3389(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY tissue: Brain. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Heart. 5. "Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation." McAvoy T., Allen P.B., Obaishi H., Nakanishi H., Takai Y., Greengard P., Nairn A.C., Hemmings H.C. Jr. Biochemistry38:12943-12949(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 7-26 AND 212-234;INTERACTION WITH PPP1R9A AND PPP1R9B strain: Sprague-Dawley. 6. Lubec G., Afjehi-Sadat L. Submitted (2006-11) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 44-60 AND 112-122;IDENTIFICATION BY MASS SPECTROMETRY strain: Sprague-Dawley. tissue: Spinal cord. 7. "The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G." Ulke-Lemee A., Trinkle-Mulcahy L., Chaulk S., Bernstein N.K., Morrice N., Glover M., Lamond A.I., Moorhead G.B.G. Biochim. Biophys. Acta1774:1339-1350(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH YLPM1

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