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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Rho guanine nucleotide exchange factor 1

SKU : BHE13801297

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1577r
Alternative Names	Lbc's second cousin ; Lsc
Categories	Elisa
Function	Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12 (By similarity). Mediates angiotensin-2-induced RhoA activation.
Specificity	Natural and recombinant Rat Rho guanine nucleotide exchange factor 1
Subcellular Location	Cytoplasm Membrane Translocated to the membrane by activated GNA13 or LPA stimulation.
Detection Range	0.312-20ng/mL
Entryname	ARHG1_RAT
Method Type	Sandwich
Platform	PF09128
Protein Name	Rho guanine nucleotide exchange factor 1
Sensitivity	0.186ng/mL
Sequence	50: MGEVAGGAAP ; GPPRSGLVSI ; IIGAEDEDFE ; NELEANPEDQ ; NSQFQSLEQV ; 100: KRRPAHLMAL ; LQHVALQFEP ; GPLLCCLHAD ; MLSSLGPKEA ; KKAFLDFYHS ; 150: FLEKTAVLRV ; PVPPSVAFEL ; DRTRPDLISE ; DVQRRFIQEV ; VQSQQAAVTR ; 200: QLEDFRSKRL ; MGMTPWEQEL ; SLLEPWIGKD ; RGNYEARERH ; VAERLLSHLE ; 250: EMQHTISTDE ; EKSAAVVTAI ; SLYMRHLGVR ; TKSGDKKSGR ; NFFRKKVMGN ; 300: RRSDEPPKTK ; KGLSSILDPA ; RWNRGEPSAP ; DCRHLKVEVD ; EKPGPADRKG ; 350: SLGISSRDRT ; VGTPGQDNPG ; VSLHPLSVDS ; LDSREPGVDT ; PQEPGDTPPQ ; 400: GPTSLEPLAP ; PESTEDNGET ; ESPEPGDDGE ; PGRSGLEQEP ; EEPPGWRELV ; 450: PSDTLLGLPK ; NQVKRQEVIS ; ELLVTEAAHV ; RMLRVLHDLF ; YQPMAEGGFF ; 500: PLEELQNIFP ; SLDELIEVHS ; LFLDRLMKRR ; QESGYLIEEI ; GDVLLARFDG ; 550: AEGSWFQKIS ; SRFCSRQSFA ; LEQLKAKQRK ; EPRFCAFVQE ; AESRPRCRRL ; 600: QLKDMIPTEM ; QRLTKYPLLL ; QSIGQNTEEP ; AERAKVELAA ; ECCREILHHV ; 650: NQAVRDMEDL ; LRLKDYQRRL ; DLTHLRQSND ; PMLSEFKNLD ; ITKKKLVHEG ; 700: PLTWRLTKDK ; AVEVHVLLLD ; DLLLLLQRQD ; EGCCSSHTSR ; TLTPTPDGKT ; 750: MLRPVLRLTS ; AMTREVATDH ; KAFYVIFTWD ; QEAQIYELVA ; QTSSERKSWC ; 800: ALITETAGSL ; KVPAPASRPK ; PRPSPSSTRE ; PLLSSSENGT ; GGTEAAPADA ; 850: RTERILNDLL ; PFCRPGPEGQ ; LAATALQKVL ; SLKQILLSTE ; EDSGAGPPRD ; 900: GDGVPGGGAP ; GPTHTQEVEE ; NLLSLEVVIK ; QLEELEEEFC ; RLRPFLSQLG ; 919: EILSPNLAAP ; ERSAQTGLS
Sequence Length	919
String	Q9Z1I6
Sub Unit	Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. Interacts with CTNNAL1. May interact with CCPG1.

Uniprot	Q9Z1I6
Gene Name	Arhgef1
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.64481

Reference	1. "Cloning of a rat homologue of lsc, a mouse oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors." Steinbrenner H., Wuensche C., Seissler J. Submitted (1999-02) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure." Guilluy C., Bregeon J., Toumaniantz G., Rolli-Derkinderen M., Retailleau K., Loufrani L., Henrion D., Scalbert E., Bril A., Torres R.M., Offermanns S., Pacaud P., Loirand G. Nat. Med.16:183-190(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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BHE13801297	E1577r	96T	$796		Add to Cart

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