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ELISA Kit for Rat Reelin

SKU : BHE13809616

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2134r
Categories	Elisa
Function	Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and ApoER2 induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.
Specificity	Natural and recombinant Rat Reelin
Subcellular Location	Secreted extracellular space extracellular matrix
Detection Range	15.6-1000pg/mL
Entryname	RELN_RAT
Method Type	Sandwich
Platform	PF02012
Protein Name	Reelin
Sensitivity	7.8pg/mL
Sequence	50: MERGCWAPRT ; LVLAVLLLLL ; ATLRARAATG ; YYPRFSPFFF ; LCTHHGELEG ; 100: DGEQGEVLIS ; LHIAGNPTYY ; VPGQEYHVTI ; STSTFFDGLL ; VTGLYTSTSI ; 150: QSSQSIGGSS ; AFGFGIMSDH ; QFGNQFMCSV ; VASHVSHLPT ; TNLSFVWIAP ; 200: PAGTGCVNFM ; ATATHRGQVI ; FKDALAQQLC ; EQGAPTEATA ; YSHLAEIHSD ; 250: SVILRDDFDS ; YHQLELNPNI ; WAECSNCDTG ; EQCGTIMHGN ; AVTFCEPYGP ; 300: RELTTTYLNT ; TTASVLQFSI ; GSGSCRFSYS ; DPSIIVSYAK ; NNTADWIQLE ; 350: KIRAPSNVST ; IIHILYLPED ; AKGENVQFQW ; KQDSLHVGEV ; YEACWALDNI ; 400: LVINSAHRQV ; ILEDSLDPVD ; TGNWLFFPGA ; TVKHSCQSDG ; NAIYFHGNEG ; 450: SQLNFATTRD ; VDLSTEDIQE ; QWSEEFESQP ; TGWDILGAVV ; GSECGTIESG ; 500: LSLVFLKDGE ; RKLCTPYMDT ; TGYGNLRFYF ; AMGGTCDPGD ; SHENDVILYA ; 550: KIEGKKEHIA ; LDTLSYSSYK ; VPTLVSVVIN ; PELQTPATKF ; CLRQKNHQGH ; 600: NQNVWAVDFF ; HVLPILPSTM ; SHMIQFSINL ; GCGTHQPGNS ; VSLEFSTNHG ; 650: RSWSLLHTEC ; LPEICAGPHL ; PHSTIYSSEN ; YSGWNRVTIP ; LPNAALTRDT ; 700: RIRWRQTGPI ; LGNMWAIDNV ; YIGPSCLKFC ; SGRGQCTRHG ; CKCDPGFSGP ; 750: ACEMASQTFP ; MFISESFGSS ; RLSSYHNFYS ; IRGAEVSFGC ; GVLASGKALV ; 800: FNKDGRRQLI ; TSFLDSSQSR ; FLQFTLRLGS ; KSVLSTCRAP ; DQPGEGVLLH ; 850: YSYDNGITWK ; LLEHYSYLNY ; HEPRIISVEL ; PDDAKQFGIQ ; FRWWQPYHSS ; 900: QGEDVWAIDE ; ILMTSVLFNS ; ISLDFTNLVE ; VTQSLGFYLG ; NIQPYCGHDW ; 950: TLCFTGDSKL ; ASSMRYVETQ ; SMQIGASYMI ; QFSLVMGCGQ ; KYTPHMDNQV ; 1000: KLEYSTNHGL ; TWHLVQDECL ; PSMPSCQEFT ; SASIYHASEF ; TQWRRVTVIL ; 1050: PQKTWSGATR ; FRWSQSYYTA ; QDEWALDDIY ; IGQQCPNMCS ; GHGSCDHGVC ; 1100: RCDQGYQGTE ; CHPEAALPST ; IMSDFENPSS ; WDSDWQEVIG ; GEVVKPEQGC ; 1150: GVVSSGSSLY ; FSKAGKRQLV ; SWDLDTSWVD ; FVQFYIQIGG ; ESAACNKPDS ; 1200: REEGVLLQYS ; NNGGIQWHLL ; AEMYFSDFGK ; PRFVYLELPA ; AAKTPCTRFR ; 1250: WWQPVFSGED ; YDQWAVDDII ; ILSEKQKQVI ; PVVNPTLPQN ; FYEKPAFDYP ; 1300: INQMSVWLML ; ANEGMAKNDS ; FCATTPSAMV ; FGKSDGDRFA ; VTRDLTLKPG ; 1350: YVLQFKLNIG ; CASQFSSTAP ; VLLQYSHDAG ; MSWFLVKEGC ; FPASAGKGCE ; 1400: GNSRELSEPT ; VYYTGDFEEW ; TRVTIAIPRS ; LASSKTRFRW ; IQESSSQKNV ; 1450: PPFGLDGVYI ; SEPCPSYCSG ; HGDCISGVCF ; CDLGYTAAQG ; TCVSNIPNHS ; 1500: EMFDRFEGKL ; SPLWYKISGG ; QVGTGCGTLS ; DGRSLYFNGL ; GKREARTVPL ; 1550: DTRNIRLVQF ; YIQIGSKTSG ; ITCIKPRARN ; EGLVVQYSND ; NGILWHLLRE ; 1600: LDFLSFLEPQ ; IISIDLPREA ; KTPATAFRWW ; QPQHGKHSAQ ; WALDDVLIGV ; 1650: NDSSQTGFQD ; KFDGSIDLQA ; NWYRIQGGQV ; DIDCLSMDTA ; LIFTENIGKP ; 1700: RYAETWDFHV ; SASSFLQFDM ; SMGCSKPFSA ; THSVQLQYSL ; NNGKDWHPVT ; 1750: EECVPPTIGC ; VHYTESSTYT ; SERFQNWRRV ; TVYLPLATNS ; PRTRFRWIQA ; 1800: NYTMGADAWA ; IDNVLLASGC ; PWLCSGRGIC ; DSGRCVCDRG ; FGGPFCVPVV ; 1850: PLPSILKDDF ; NGNLHPDLWP ; EVYGAERGNL ; NGETIKSGTS ; LIFKGEGLRM ; 1900: LISRDLDCTN ; TMYVQFSLRF ; IAKGTPERSH ; SILLQSSING ; GVTWRLMDEF ; 1950: YFPQTTSILF ; INVPLPYSAQ ; TNATRFRLWQ ; PYNNGKKEEI ; WIIDDFIIDG ; 2000: DNLNNPVMLL ; DTFDFGPRED ; NWFFYPGGNI ; GLYCPYSSKG ; APEEDSAMVF ; 2050: VSNEIGEHSI ; TTRDLSVNEN ; TIIQFEINVG ; CSTDSSSADP ; VRLEFSRDFG ; 2100: ATWHLLLPLC ; YHSSSLVSSL ; CSTEHHPSST ; YYAGTTQGWR ; REVVHFGKLH ; 2150: LCGSVRFRWY ; QGFYPAGSQP ; VTWAIDNVYI ; GPQCEEMCCG ; HGSCVNGTKC ; 2200: ICDPGYSGPT ; CKISTKNPDF ; LKDDFEGQLE ; SDRFLLMSGG ; KPSRKCGILS ; 2250: SGNNLFFNED ; GLRMLVTRDL ; DLSHARFVQF ; FMRLGCGKGV ; PDPRSQPVLL ; 2300: QYSLNGGLSW ; SLLQEFLFSN ; SSNVGRYIAL ; EMPLKARSGS ; TRLRWWQPSE ; 2350: NGHFYSPWVI ; DQILIGGNIS ; GNTVLEDDFS ; TLDSRKWLLH ; PGGTKMPVCG ; 2400: STGDALVFIE ; KASTRYVVTT ; DIAVNEDSFL ; QIDFAASCSV ; TDSCYAIELE ; 2450: YSVDLGLSWH ; PLVRDCLPTN ; VECSRYHLQR ; ILVSDTFNKW ; TRITLPLPAY ; 2500: TRSQATRFRW ; HQPAPFDKQQ ; TWAIDNVYIG ; DGCLDMCSGH ; GRCIQGSCVC ; 2550: DEQWGGLYCD ; EPETSLPTQL ; KDNFNRAPSN ; QNWLTVNGGK ; LSTVCGAVAS ; 2600: GLALHFSGGC ; SRLLVTVDLN ; LTNAEFIQFY ; FMYGCLITPS ; NRNQGVLLEY ; 2650: SVNGGITWTL ; LMEIFYDQYS ; KPGFVNILLP ; PDAKEIGTRF ; RWWQPRHDGL ; 2700: DQNDWAIDNV ; LISGSADQRT ; VMLDTFSSAP ; VPQHERSPAD ; AGPVGRIAFD ; 2750: MFMEDKTSVN ; ENWVFHDDCT ; VERFCDSPDG ; VMLCGSHDGR ; EVYAVTHDLT ; 2800: PTENWIMQFK ; ISVGCKVPEK ; IAQNQIHVQF ; STDFGVSWSY ; LVPQCLPADP ; 2850: KCSGTVSQPS ; VFFPTKGWKR ; ITYPLPESLM ; GNPVRFRFYQ ; KYSDVQWAID ; 2900: NFYLGPGCLD ; NCGGHGDCLK ; EQCICDPGYS ; GPHCYLTHTL ; KTFLKERFDS ; 2950: EEIKPDLWMS ; LEGGSTCTEC ; GILAENTALY ; FGGSTVRQAI ; TQDLDLRGAK ; 3000: FLQYWGRIGS ; ENNMTSCHRP ; VCRKEGVLLD ; YSKDGGITWT ; LLHEMDFQKY ; 3050: ISVRHDYILL ; PEGALTNTTR ; LRWWQPFVIS ; NGLVVSGVER ; AQWALDNILI ; 3100: GGAEINPSQL ; VDTFDDEGSS ; HEENWSFYPN ; AVRTAGFCGN ; PSFHLYWPNK ; 3150: KKDKTHNALS ; SRELIIQPGY ; MMQFKIVVGC ; EATSCGDLHS ; VMLEYTKDAR ; 3200: SDSWQLVQTQ ; CLPSSSNSIG ; CSPFQFHEAT ; IYNAVNSSSW ; KRITIQLPDH ; 3250: VSSSATQFRW ; IQKGEETEKQ ; SWAIDHVYIG ; EACPRLCSGH ; GYCTTGAVCI ; 3300: CDESFQGDDC ; SVFSHELPSY ; IKDNFESARV ; TEANWETIQG ; GAIGSGCGQL ; 3350: APYAHGDSLY ; FNGCQIRQAA ; TKPLDLTRAS ; KIMFVLQIGS ; TAQTDSCNSD ; 3400: LSGPHTVDKA ; VLLQYSVNNG ; ITWHVIAQHQ ; PKDFTQAQRV ; SYNVPLEARM ; 3450: KGVLLRWWQP ; RHNGTGHDQW ; ALDHVEVVLV ; STRKQNYMMN ; FSRQHGLRHF ; 3462: YNRRRRSLRR ; YP
Sequence Length	3462
String	P58751
Sub Unit	Binds to the ectodomains of VLDLR and ApoER2.

Uniprot	P58751
Gene Name	Reln
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:24718
Unigene	Rn.98353

Reference	1. Kikkawa S., Terashima T. Submitted (2000-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) tissue: Cerebellum. 2. "Rat neurological disease creeping is caused by a mutation in the reelin gene." Yokoi N., Namae M., Wang H.-W., Kojima K., Fuse M., Yasuda K., Serikawa T., Seino S., Komeda K. Brain Res. Mol. Brain Res.112:1-7(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DISEASE tissue: Cerebellum. 3. "Evolutionarily conserved, alternative splicing of reelin during brain development." Lambert de Rouvroit C., Bernier B., Royaux I., de Bergeyck V., Goffinet A.M. Exp. Neurol.156:229-238(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING

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