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ELISA Kit for Rat Receptor tyrosine-protein kinase erbB-4

SKU : BHE13803547

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9560r
Alternative Names	Proto-oncogene-like protein c-ErbB-4 ; Tyro-2
Categories	Elisa
Function	Specifically binds and is activated by neuregulins, including NRG2 and NRG3, HBEGF, BTC and NTAK. Interaction with these factors induces cell differentiation. Plays a role in the regulation of cell growth and cell proliferation. The C-terminal fragment (CTF) of isoform JMA-A CYT-2 (containing E4ICD2) can stimulate transcription in the presence of YAP1. Conflicting reports are likely due at least in part to the opposing effects of the isoform-specific and nuclear-translocated ERBB4 intracellular domains (E4ICD1 and E4ICD2). Overexpression studies in epithelium show growth inhibition using E4ICD1 and increased proliferation using E4ICD2. E4ICD2 has greater in vitro kinase activity than E4ICD1. The kinase activity is required for the nuclear translocation of E4ICD2.
Specificity	Natural and recombinant Rat Receptor tyrosine-protein kinase erbB-4
Subcellular Location	ERBB4 intracellular domain Nucleus Following proteolytical processing E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD2 derived from processing of isoform JM-A CYT-2 colocalizes with YAP1 in the nucleus.
Detection Range	0.625-40ng/mL
Entryname	ERBB4_RAT
Method Type	Sandwich
Platform	PF00757
Protein Name	Receptor tyrosine-protein kinase erbB-4
Sensitivity	0.294ng/mL
Sequence	50: MKLATGLWVW ; GSLLVAARTV ; QPSASQSVCA ; GTENKLSSLS ; DLEQQYRALR ; 100: KYYENCEVVM ; GNLEITSIEH ; NRDLSFLRSI ; REVTGYVLVA ; LNQFRYLPLE ; 150: NLRIIRGTKL ; YEDRYALAIF ; LNYRKDGNFG ; LQELGLKNLT ; EILNGGVYVD ; 200: QNKFLCYADT ; IHWQDIVRNP ; WPSNMTLVST ; IGSSGCGRCH ; KSCTGRCWGP ; 250: TENHCQTLTR ; TVCAEQCDGR ; CYGPYVSDCC ; HRECAGGCSG ; PKDTDCFACM ; 300: NFNDSGACVT ; QCPQTFVYNP ; TTFQLEHNFN ; AKYTYGAFCV ; KKCPHNFVVD ; 350: SSSCVRACPS ; SKMEVEENGI ; KMCKPCTDIC ; PKACDGIGTG ; SLMSAQTVDS ; 400: SNIDKFINCT ; KINGNLIFLV ; TGIHGDPYNA ; IDAIDPEKLN ; VFRTVREITG ; 450: FLNIQTWPPN ; MTDFSVFSNL ; VTIGGRVLYS ; GLSLLILKQQ ; GITSLQFQSL ; 500: KEISAGNIYI ; TDNSNLCYYH ; TINWTTLFST ; VNQRIVIRDN ; RRAENCTAEG ; 550: MVCNHLCSND ; GCWGPGPDQC ; LSCRRFSRGK ; ICIESCNLYD ; GEFREFENGS ; 600: ICVECDSQCE ; KMEDGLLTCH ; GPGPDNCTKC ; SHFKDGPNCV ; EKCPDVLQGA ; 650: NSFIFKYADQ ; DRECHPCHPN ; CTQGCNGPTS ; HDCIYYPWTG ; HSTLPQHART ; 700: PLIAAGVIGG ; LFILVIMALT ; FAVYVRRKSI ; KKKRALRRFL ; ETELVEPLTP ; 750: SGTAPNQAQL ; RILKETELKR ; VKVLGSGAFG ; TVYKGIWVPE ; GETVKIPVAI ; 800: KILNETTGPK ; ANVEFMDEAL ; IMASVDHPHL ; VRLLGVCLSP ; TIQLVTQLMP ; 850: HGCLLEYVHE ; HKDNIGSQLL ; LNWCVQIAKG ; MMYLEERRLV ; HRDLAARNVL ; 900: VKSPNHVKIT ; DFGLARLLEG ; DEKEYNADGG ; KMPIKWMALE ; CIHYRKFTHQ ; 950: SDVWSYGVTI ; WELMTFGGKP ; YDGIPTREIP ; DLLEKGERLP ; QPPICTIDVY ; 1000: IVMVKCWMID ; ADSRPKFKEL ; AAEFSRMARD ; PQRYLVIQGD ; DRMKLPSPND ; 1050: SKFFQNLLDE ; EDLEDMMDAE ; EYLVPQAFNI ; PPPIYTSRTR ; IDSNRSEIGH ; 1100: SPPPAYTPMS ; GSQFVYQDGG ; FATQQGMPMP ; YTATTSTIPE ; APVAQGATAE ; 1150: MFDDSCCNGT ; LRKPVVPHVQ ; EDSSTQRYSA ; DPTVFAPERN ; PRAELDEEGY ; 1200: MTPMHDKPKQ ; EYLNPVEENP ; FVSRRKNGDL ; QALDNPEYHS ; ASSGPPKAED ; 1250: EYVNEPLYLN ; TFTNALGNAE ; YMKNSLLSVP ; EKAKKAFDNP ; DYWNHSLPPR ; 1300: STLQHPDYLQ ; EYSTKYFYKQ ; NGRIRPIVAE ; NPEYLSEFSL ; KPGTMLPPPP ; 1308: YRHRNTVV
Sequence Length	1308
String	Q62956
Sub Unit	Homodimer or heterodimer with another ERBB family member. Interacts with GRB7 (By similarity). Interacts with CBFA2T3. Interacts with DLG2 (via its PDZ domain), DLG3 (via its PDZ domain), DLG4 (via its PDZ domain) and SNTB2 (via its PDZ domain). Interacts with MUC1. Interacts (via its PPxy motifs) with WWOX. Interacts (via the PPxY motif 3 of isoform JM-A CYT-2) with YAP1 (via the WW domain 1 of isoform 1). Interacts (isoform JM-A CYT-1 and isoform JM-B CYT-1) with WWP1. Interacts (via its intracellular domain) with TRIM28. Interacts (via the intracellular domains of both CYT-1 and CYT-2 isoforms) with KAP1; the interaction does not phosphorylate KAP1 but represses ERBB4-mediated transcriptional activity. Interacts with PRPU, DDX23, MATR3, RBM15, ILF3, KAP1, U5S1, U2SURP, ITCH, HNRPU, AP2A1, NULC, LEO1, WWP2, IGHG1, HXK1 AND ARS2.

Uniprot	Q62956
Gene Name	Erbb4
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:59323
Unigene	Rn.163078

Reference	1. "Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes." Zhao Y.-Y., Sawyer D.R., Baliga R.R., Opel D.J., Han X., Marchionni M.A., Kelly R.A. J. Biol. Chem.273:10261-10269(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM JM-A CYT1) tissue: Heart. 2. "ErbB4 expression in neural progenitor cells (ST14A) is necessary to mediate neuregulin-1-beta1-induced migration." Gambarotta G., Garzotto D., Destro E., Mautino B., Giampietro C., Cutrupi S., Dati C., Cattaneo E., Fasolo A., Perroteau I. J. Biol. Chem.279:48808-48816(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS JM-A CYT1 AND JM-A CYT2) strain: Wistar. tissue: Olfactory bulb. 3. "An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system." Lai C., Lemke G. Neuron6:691-704(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 848-901 tissue: Sciatic nerve. 4. "Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration." Carroll S.L., Miller M.L., Frohnert P.W., Kim S.S., Corbett J.A. J. Neurosci.17:1642-1659(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1031-1198 strain: Sprague-Dawley. tissue: Spinal cord. 5. "Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses." Huang Y.Z., Won S., Ali D.W., Wang Q., Tanowitz M., Du Q.S., Pelkey K.A., Yang D.J., Xiong W.C., Salter M.W., Mei L. Neuron26:443-455(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 6. "Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt." Fukazawa R., Miller T.A., Kuramochi Y., Frantz S., Kim Y.D., Marchionni M.A., Kelly R.A., Sawyer D.B. J. Mol. Cell. Cardiol.35:1473-1479(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION 7. "Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts." Ma L., Huang Y.Z., Pitcher G.M., Valtschanoff J.G., Ma Y.H., Feng L.Y., Lu B., Xiong W.C., Salter M.W., Weinberg R.J., Mei L. J. Neurosci.23:3164-3175(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION 8. "Stimulated ErbB4 internalization is necessary for neuregulin signaling in neurons." Liu Y., Tao Y.M., Woo R.S., Xiong W.C., Mei L. Biochem. Biophys. Res. Commun.354:505-510(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS NRG1 RECEPTOR IN ACTIVATION OF AKT1 AND THE MAP KINASES MAPK1/ERK2 AND/OR MAPK3/ERK1;SUBCELLULAR LOCATION 9. "The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity." Li B., Woo R.S., Mei L., Malinow R. Neuron54:583-597(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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