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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Receptor-type tyrosine-protein phosphatase C

SKU : BHE13808748

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1030r
Alternative Names	Leukocyte common antigen ; L-CA ; T200 ; CD45
Categories	Elisa
Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN.
Specificity	Natural and recombinant Rat Receptor-type tyrosine-protein phosphatase C
Subcellular Location	Membrane Single-pass type I membrane protein Membrane raft Colocalized with DPP4 in membrane rafts.
Entryname	PTPRC_RAT
Platform	PF00041
Protein Name	Receptor-type tyrosine-protein phosphatase C
Sequence	50: MYLWLKLLAF ; SLALLGPEVF ; VTGQGTTDDG ; LDTTEIVLLP ; QTDPLPARTT ; 100: EFTPPSISER ; GNGSSETTYL ; PGFSSTLMPH ; LTPQPDSQTP ; SARGADTQTL ; 150: SSQADLTTLT ; AAPSGETDPP ; GVPEESTVPE ; TFPGGTPILA ; RNSTAPSPTH ; 200: TSNVSTTDIS ; SGANLTTPAP ; STLGFASNTT ; TSTEIATPQT ; KPSCDEKFGN ; 250: VTVRYIYDDS ; SKNFNANLEG ; DKKPKCEYTD ; CEKELKNLPE ; CSQKNVTLSN ; 300: GSCTPDKIIN ; LDVPPGTHNF ; NLTNCTPDIE ; ANTSICLEWK ; IKNKFTCDIQ ; 350: KISYNFRCTP ; EMKTFALDKH ; GTLWLHNLTV ; RTNYTCAAEV ; LYNNVILLKQ ; 400: DRRVQTDFGT ; PEMLPHVQCK ; NSTNSTTLVS ; WAEPASKHHG ; YILCYKKTPS ; 450: EKCENLANDV ; NSFEVKNLRP ; YTEYTVSLFA ; YVIGRVQRNG ; PAKDCNFRTK ; 500: AARPGKVNGM ; KTSRASDNSI ; NVTCNSPYEI ; NGPEARYILE ; VKSGGSLVKT ; 550: FNQSTCKFVV ; DNLYYSTDYE ; FLVYFYNGEY ; LGDPEIKPQS ; TSYNSKALII ; 600: FLVFLIIVTS ; IALLVVLYKI ; YDLRKKRSSN ; LDEQQELVER ; DEEKQLINVD ; 650: PIHSDLLLET ; YKRKIADEGR ; LFLAEFQSIP ; RVFSKFPIKD ; ARKSQNQNKN ; 700: RYVDILPYDY ; NRVELSEING ; DAGSTYINAS ; YIDGFKEPRK ; YIAAQGPRDE ; 750: TVDDFWKMIW ; EQKATVIVMV ; TRCEEGNRNK ; CAEYWPCMEE ; GTRTFRDVVV ; 800: TINDHKRCPD ; YIIQKLSIAH ; KKEKATGREV ; THIQFTSWPD ; HGVPEDPHLL ; 850: LKLRRRVNAF ; SNFFSGPIVV ; HCSAGVGRTG ; TYIGIDAMLE ; SLEAEGKVDV ; 900: YGYVVNLRRQ ; RCLMVQVEAQ ; YILIHQALVE ; YNQFGETEVN ; LSELHSCLQN ; 950: LKKRDPPSDP ; SPLEAEYQRL ; PSYRSWRTQH ; IGNQEENKKK ; NRSSNVVPYD ; 1000: FNRVPLKHEL ; EMSKESEAES ; DESSDEDSDS ; EETSKYINAS ; FVMSYWKPEM ; 1050: MIAAQGPLKE ; TIGDFWQMIF ; QRKVKVIVML ; TELMSGDQEV ; CAQYWGEGKQ ; 1100: TYGDMEVMLK ; DTNKSSAYIL ; RAFELRHSKR ; KEPRTVYQYQ ; CTTWKGEELP ; 1150: AEPKDLVTLI ; QNIKQKLPKS ; GSEGMKYHKH ; ASILVHCRDG ; SQQTGLFCAL ; 1200: FNLLESAETE ; DVVDVFQVVK ; SLRKARPGMV ; GSFEQYQFLY ; DIMASIYPTQ ; 1250: NGQVKKANSQ ; DKIEFHNEVD ; GAKQDANCVQ ; PADPLNKAQE ; DSKEVGASEP ; 1273: ASGSEEPEHS ; ANGPMSPALT ; PSS
Sequence Length	1273
String	P04157
Sub Unit	Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Binds GANAB and PRKCSH.

Uniprot	P04157
Gene Name	Ptprc
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:24699
Unigene	Rn.90166

Reference	1. "Amgen rat EST program." Amgen EST program Submitted (2003-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-147 (ISOFORM 4) 2. "Lymphocyte specific heterogeneity in the rat leucocyte common antigen (T200) is due to differences in polypeptide sequences near the NH2-terminus." Barclay A.N., Jackson D.I., Willis A.C., Williams A.F. EMBO J.6:1259-1264(1987) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-218 (ISOFORMS 1; 2; 3 AND 4) 3. Barclay A.N., Jackson D.I., Willis A.C., Williams A.F. Submitted (1987-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-1273 (ISOFORMS 1; 3; 4 AND 5) 4. "Evidence from cDNA clones that the rat leukocyte-common antigen (T200) spans the lipid bilayer and contains a cytoplasmic domain of 80,000 Mr." Thomas M.L., Barclay A.N., Gagnon J., Williams A.F. Cell41:83-93(1985) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-1255 (ISOFORM 1)

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808748	E1030r	96T	$796		Add to Cart

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