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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Receptor-interacting serine/threonine-protein kinase 3

SKU : BHE13809865

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11168r
Alternative Names	Homocysteine respondent protein HCYP2 ; RIP-like protein kinase 3 ; Receptor-interacting protein 3 ; RIP-3 ; Rip3
Categories	Elisa
Function	Essential for cellular necroptosis in response to TNF-alpha family of death-inducing cytokines. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Specificity	Natural and recombinant Rat Receptor-interacting serine/threonine-protein kinase 3
Subcellular Location	Cytoplasm Cell membrane Mitochondrion
Detection Range	0.156-10ng/mL
Entryname	RIPK3_RAT
Method Type	Sandwich
Platform	PF00069
Protein Name	Receptor-interacting serine/threonine-protein kinase 3
Sensitivity	0.088ng/mL
Sequence	50: MSSVKLWLNG ; ASSISLVGSE ; ELENLGFVGK ; GGFGAVFRAR ; HTAWNLDVAV ; 100: KIVNSKKISR ; EVKAMVNLRH ; ENVLLLLGVT ; ENLEWDYVYG ; PALVTGFMEN ; 150: GSLSGLLQPS ; CPRPWPLLCR ; LLEEVVLGMC ; YLHSLNPSLL ; HRDLKPSNVL ; 200: LDLELHAKLA ; DFGLSTFQGG ; SQSGSGSGSR ; DSGGTLAYLA ; PELLDNDGKA ; 250: SKASDVYSFG ; VLVWTVLAGR ; EAEVVDKTSL ; IRGAVCNRQR ; RPPLTELPPD ; 300: SPETPGLEGL ; KELMTHCWSS ; EPKDRPSFQD ; CESKTNNVYI ; LVQDKVDAAV ; 350: SKVKHYLSQY ; RSSDTKLSAR ; ESSQKGTEVD ; CPRETIVYEM ; LDRLHLEEPS ; 400: GSVPERLTSL ; TERRGKEASF ; GHATPAGTSS ; DTLAGTPQIP ; HTLPSRGTTP ; 450: RPAFTETPGP ; DPQRNQGDGR ; NSNPWYTWNA ; PNPMTGLQSI ; VLNNCSEVQI ; 478: GQHNCMSVQP ; RTAFPKKEPA ; QFGRGRGW
Sequence Length	478
String	Q9Z2P5
Sub Unit	Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necroptosis-inducing complex. Binds TRAF2 is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes.

Uniprot	Q9Z2P5
Gene Name	Ripk3
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:246240
Unigene	Rn.7110

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809865	E11168r	96T	$796		Add to Cart

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