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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Ras-related C3 botulinum toxin substrate 1

SKU : BHE13809381

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15264r
Alternative Names	p21-Rac1
Categories	Elisa
Function	Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.
Specificity	Natural and recombinant Rat Ras-related C3 botulinum toxin substrate 1
Subcellular Location	Cell membrane Lipid-anchor Cytoplasmic side Melanosome Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine.
Entryname	RAC1_RAT
Platform	PF00071
Protein Name	Ras-related C3 botulinum toxin substrate 1
Sequence	50: MQAIKCVVVG ; DGAVGKTCLL ; ISYTTNAFPG ; EYIPTVFDNY ; SANVMVDGKP ; 100: VNLGLWDTAG ; QEDYDRLRPL ; SYPQTDVFLI ; CFSLVSPASF ; ENVRAKWYPE ; 150: VRHHCPNTPI ; ILVGTKLDLR ; DDKDTIEKLK ; EKKLTPITYP ; QGLAMAKEIG ; 192: AVKYLECSAL ; TQRGLKTVFD ; EAIRAVLCPP ; PVKKRKRKCL ; LL
Sequence Length	192
String	Q6RUV5
Sub Unit	Interacts with the GEF proteins PREX1, RASGRF2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with BAIAP2, BAIAP2L1, PLXNB1, CYFIP1/SRA-1 and DEF6. Part of a complex with MAP2K3, MAP3K3 and CCM2. Interacts with NISCH and NOXA1. Interacts with ARHGEF2. Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts with DSCAM; the interaction requires PAK1 (By similarity). Interacts with TBC1D2 (By similarity). Interacts with UNKL (By similarity). Interacts with USP6 (By similarity). Interacts with SPATA13 (By similarity). Interacts with ARHGEF16; mediates activation of RAC1 by EPHA2. Interacts with ITGB4.

Uniprot	Q6RUV5
Gene Name	Rac1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:363875
Unigene	Rn.29157

Reference	1. "Possible role of direct Rac1-Rab7 interaction in ruffled border formation of osteoclasts." Sun Y., Bueki K.G., Ettala O., Vaeaeraeniemi J.P., Vaeaenaenen H.K. J. Biol. Chem.280:32356-32361(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH RAB7A strain: Wistar. tissue: Bone marrow. 2. Lubec G., Kang S.U. Submitted (2007-07) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 6-16; 103-116; 133-147; 154-163 AND 167-183;IDENTIFICATION BY MASS SPECTROMETRY strain: Sprague-Dawley. tissue: Brain. 3. "Rac GTPase signaling through the PP5 protein phosphatase." Gentile S., Darden T., Erxleben C., Romeo C., Russo A., Martin N., Rossie S., Armstrong D.L. Proc. Natl. Acad. Sci. U.S.A.103:5202-5206(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PPP5C;MUTAGENESIS OF GLN-61 4. "Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease." Shibata S., Nagase M., Yoshida S., Kawarazaki W., Kurihara H., Tanaka H., Miyoshi J., Takai Y., Fujita T. Nat. Med.14:1370-1376(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF GLY-12 5. "Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase." Li X., Lee A.Y. J. Biol. Chem.285:32436-32445(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PLXNB3 AND ARHGDIA;SUBCELLULAR LOCATION 6. "Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism." Duffney L.J., Wei J., Cheng J., Liu W., Smith K.R., Kittler J.T., Yan Z. J. Neurosci.33:15767-15778(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIN POLYMERIZATION;MUTAGENESIS OF THR-17 AND GLN-61

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