Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A.
Specificity
Natural and recombinant Rat Rab GTPase-binding effector protein 1
Subcellular Location
Cytoplasm Early endosome Recycling endosome Cytoplasmic vesicle
Heterodimer with RABGEF1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2 (By similarity). Interacts with ECM29.
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