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ELISA Kit for Rat Proto-oncogene tyrosine-protein kinase receptor Ret

SKU : BHE13809130

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15070r
Categories	Elisa
Function	Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.
Specificity	Natural and recombinant Rat Proto-oncogene tyrosine-protein kinase receptor Ret
Subcellular Location	Cell membrane Single-pass type I membrane protein Endosome membrane Single-pass type I membrane protein
Detection Range	0.156-10ng/ml
Entryname	RET_RAT
Method Type	Sandwich
Platform	PF00028
Protein Name	Proto-oncogene tyrosine-protein kinase receptor Ret
Sensitivity	0.09ng/mL
Sequence	50: MAKARSGAAG ; LGLKLFLLLP ; LLGEAPLGLY ; FSRDAYWERL ; YVDQPAGTPL ; 100: LYVHALRDAP ; GEVPSFRLGQ ; YLYGVYRTRL ; HENDWIHIDS ; GTGLLYLNQS ; 150: LDHSSWEQLS ; IRNGGFPLLT ; VFLQVFLGST ; AQREGECHWP ; GCARVYFSFI ; 200: NDTFPNCSSF ; KARDLCTPET ; GVSFRIRENR ; PPGTFYQFRM ; LPVQFLCPNI ; 250: SVKYKLLEGD ; GLPFRCDPDC ; LEVSTRWALD ; RELQEKYVLE ; AECAVAGPGA ; 300: NKEKVAVSFP ; VTVYDEDDSP ; PTFSGGVGTA ; SAVVEFKRKE ; GTVVATLQVF ; 350: DADVVPASGE ; LVRRYTSTLL ; SGDSWAQQTF ; RVEHTPNETL ; VQSNNNSVRA ; 400: TMHNYKLVLN ; RSLSISESRV ; LQLVVLVNDS ; DFQGPGSGVL ; FLHFNVSVLP ; 450: VTLNLPMAYS ; FPVNRRARRY ; AQIGKVCVEN ; CQEFSGVSIQ ; YKLQPSSTNC ; 500: SALGVVTSTE ; DTSGTLYVND ; TEALRRPECT ; ELQYTVVATD ; RQTRRQTQAS ; 550: LVVTVEGTYI ; AEEVGCPKSC ; AVNKRRPECE ; ECGGLGSPTG ; RCEWRQGDGK ; 600: GITRNFSTCS ; PSTRTCPDGH ; CDALESRDIN ; ICPQDCLRGP ; IVGGHERGER ; 650: QGIKAGYGIC ; NCFPDEKKCF ; CEPEDSQGPL ; CDELCRTVIT ; AAVLFSFIIS ; 700: VLLSTFCIHR ; YHKHAHKPPI ; ASAEMTFCRP ; AQGFPISYSS ; SGTRRPSLDS ; 750: MENQVSVDSF ; KIPEDPKWEF ; PRKNLVLGKT ; LGEGEFGKVV ; KATAFRLKGR ; 800: AGYTTVAVKM ; LKENASQSEL ; RDLLSEFNLL ; KQVNHPHVIK ; LYGACSQDGP ; 850: LLLIVEYAKY ; GSLRGFLRDS ; RKIGPAYVSS ; GGSRNSSSLD ; HPDERVLTMG ; 900: DLISFAWQIS ; RGMQYLAEMK ; LVHRDLAARN ; ILVAEGRKMK ; ISDFGLSRDV ; 950: YEEDSYVKKS ; KGRIPVKWMA ; IESLFDHIYT ; TQSDVWSFGV ; LLWEIVTLGG ; 1000: NPYPGIPPER ; LFNLLKTGHR ; MERPDNCSEE ; MYRLMLQCWK ; QEPDKRPVFA ; 1050: DISKDLEKMM ; VKSRDYLDLA ; ASTPSDSLLY ; DDGLSEEETP ; LVDCNSAPLP ; 1100: RSLPSTWIEN ; KLYGMSDPNW ; PGESPVPLTR ; ADGTSTGFPR ; YANDSVYANW ; 1115: MVSPSAAKLM ; DTFDS
Sequence Length	1115
Sub Unit	Phosphorylated form interacts with the PBT domain of DOK2, DOK4 and DOK5. The phosphorylated form interacts with PLCG1 and GRB7. Interacts (not phosphorylated) with CC PTK2/FAK1 (via FERM domain). Extracellular cell-membrane anchored RET cadherin fragments form complex in neurons with reduced trophic status, preferentially at the contact sites between somas. Interacts with AIP in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex. Binds to ARTN. Interacts (inactive) with CBLC and CD2AP; dissociates upon activation by GDNF which increases CBLC:CD2AP interaction.

Uniprot	G3V9H8
Gene Name	Ret
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:24716
Unigene	Rn.93200

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809130	E15070r	96T	$796		Add to Cart

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