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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Protein S100-A8

SKU : BHE13810331

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1792r
Alternative Names	Calgranulin-A ; Migration inhibitory factor-related protein 8 ; MRP-8 ; S100 calcium-binding protein A8 ; Mrp8
Categories	Elisa
Function	Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS) (By similarity). Promotes tubulin polymerization. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions (By similarity). Has maximal chemotactic activity for neutrophils. May play an important role in cellular immune reactions.
Specificity	Natural and recombinant Rat Protein S100-A8
Subcellular Location	Secreted Cytoplasm Cytoplasm cytoskeleton Cell membrane Peripheral membrane protein Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes.
Detection Range	3.12-200ng/mL
Entryname	S10A8_RAT
Method Type	Sandwich
Platform	PF01023
Protein Name	Protein S100-A8
Sensitivity	1.64ng/mL
Sequence	50: MATELEKALS ; NVIEVYHNYS ; GIKGNHHALY ; RDDFRKMVTT ; ECPQFVQNKN ; 89: TESLFKELDV ; NSDNAINFEE ; FLVLVIRVGV ; AAHKDSHKE
Sequence Length	89
String	P50115
Sub Unit	Homodimer. Heterotetramer with S100A9. Component of the heterotetrameric calprotectin complex containing two copies each of S100A8 and S100A9. Interacts with AGER and with the heterodimeric complex formed by TLR4 and LY96. Interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner. Heterotetrameric calprotectin interacts with ANXA6 and associates with tubulin filaments in activated monocytes. May interact with components of the intermediate filaments in monocytes and epithelial cells.

Uniprot	P50115
Gene Name	S100a8
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:116547
Unigene	Rn.31839

Reference	1. "Expression and cloning of migration inhibitory factor-related protein (MRP)8 and MRP14 in arthritis-susceptible rats." Imamichi T., Uchida I., Wahl S.M., McCartney-Francis N. Biochem. Biophys. Res. Commun.194:819-825(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Lewis/N. tissue: Peritoneal cavity. 2. "Identification of posttranslational modifications and cDNA sequencing errors in the rat S100 proteins MRP8 and 14 using electrospray ionization mass spectrometry." Raftery M.J., Geczy C.L. Anal. Biochem.258:285-292(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-89;MASS SPECTROMETRY;ACETYLATION AT ALA-2 tissue: Spleen. 3. "Dynamic mobility of immunological cells expressing S100A8 and S100A9 in vivo: a variety of functional roles of the two proteins as regulators in acute inflammatory reaction." Koike A., Arai S., Yamada S., Nagae A., Saita N., Itoh H., Uemoto S., Totani M., Ikemoto M. Inflammation35:409-419(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810331	E1792r	96T	$796		Add to Cart

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