Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
Specificity
Natural and recombinant Rat Protein ERGIC-53
Subcellular Location
Endoplasmic reticulum-Golgi intermediate compartment membrane Single-pass type I membrane protein Golgi apparatus membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein
Exists both as a covalent disulfide-linked homohexamer, and a complex of three disulfide-linked dimers non-covalently kept together. Interacts with MCFD2.
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