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ELISA Kit for Rat Protein DJ-1

SKU : BHE13807885

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3064r
Alternative Names	Contraception-associated protein 1 ; Protein CAP1 ; Fertility protein SP22 ; Parkinson disease protein 7 homolog ; Protein deglycase DJ-1 ; 3.1.2.- ; Cap1
Categories	Elisa
Function	Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone.
Specificity	Natural and recombinant Rat Protein DJ-1
Subcellular Location	Cytoplasm Nucleus Mitochondrion Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage.
Entryname	PARK7_RAT
Platform	PF01965
Protein Name	Protein DJ-1
Sequence	50: MASKRALVIL ; AKGAEEMETV ; IPVDIMRRAG ; IKVTVAGLAG ; KDPVQCSRDV ; 100: VICPDTSLEE ; AKTQGPYDVV ; VLPGGNLGAQ ; NLSESALVKE ; ILKEQENRKG ; 150: LIAAICAGPT ; ALLAHEVGFG ; CKVTSHPLAK ; DKMMNGSHYS ; YSESRVEKDG ; 189: LILTSRGPGT ; SFEFALAIVE ; ALSGKDMANQ ; VKAPLVLKD
Sequence Length	189
String	O88767
Sub Unit	Homodimer. Binds EFCAB6/DJBP and PIAS2. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR. Interacts (via N-terminus) with OTUD7B. Interacts with HIPK1, BBS1, CLCF1 and MTERF (By similarity). Part of a ternary RNA-binding complex.

Uniprot	O88767
Gene Name	Park7
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:117287
Unigene	Rn.30105

Reference	1. "Molecular cloning and expression of rat contraception associated protein 1 (CAP1), a protein putatively involved in fertilization." Wagenfeld A., Gromoll J., Cooper T.G. Biochem. Biophys. Res. Commun.251:545-549(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 13-29 AND 65-74;TISSUE SPECIFICITY tissue: Testis. 2. "SP22: a novel fertility protein from a highly conserved gene family." Welch J.E., Barbee R.R., Roberts N.L., Suarez J.D., Klinefelter G.R. J. Androl.19:385-393(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Testis. 3. Welch J.E., Barbee R.R., Roberts N.L., Suarez J.D., Klinefelter G.R. Submitted (1999-06) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Testis. 4. "Identification and characterization of a novel protein that regulates RNA-protein interaction." Hod Y., Pentyala S.N., Whyard T.C., El-Maghrabi M.R. J. Cell. Biochem.72:435-444(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-45;ASSOCIATION WITH AN RNA-BINDING COMPLEX;SUBCELLULAR LOCATION 5. Lubec G., Afjehi-Sadat L., Chen W.-Q., Kang S.U. Submitted (2007-07) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 33-48; 63-89; 100-122; 133-145 AND 157-175;IDENTIFICATION BY MASS SPECTROMETRY strain: Sprague-Dawley. tissue: Brain. tissue: Hippocampus. tissue: Spinal cord.

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