May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF.
Specificity
Natural and recombinant Rat Proheparin-binding EGF-like growth factor
Subcellular Location
Proheparin-binding EGF-like growth factor Cell membrane Single-pass type I membrane protein