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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Programmed cell death protein 4

SKU : BHE13808382

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2393r
Alternative Names	Death up-regulated gene protein ; Dug
Categories	Elisa
Function	Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.
Specificity	Natural and recombinant Rat Programmed cell death protein 4
Subcellular Location	Nucleus Cytoplasm Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457.
Detection Range	0.312-20ng/mL
Entryname	PDCD4_RAT
Method Type	Sandwich
Platform	PF02847
Protein Name	Programmed cell death protein 4
Sensitivity	0.16ng/mL
Sequence	50: MDVENEQILN ; VNPTDPDNLS ; DSLFSGDEEN ; AGTEEIKNEI ; NGNWISASTI ; 100: NEARINAKAK ; RRLRKNSSRD ; SGRGDSVSDN ; GSEAVRSGVA ; VPTSPKGRLL ; 150: DRRSRSGKGR ; GLPKKGGAGG ; KGVWGTPGQV ; YDVEEVDVKD ; PNYDDDQENC ; 200: VYETVVLPLD ; ETAFEKTLTP ; IIQEYFEHGD ; TNEVAEMLRD ; LNLGEMKSGV ; 250: PVLAVSLALE ; GKASHREMTS ; KLLSDLCGTV ; MSTNDVEKSF ; DKLLKDLPEL ; 300: ALDTPRAPQL ; VGQFIARAVG ; DGILCNTYID ; SYKGTVDCVQ ; ARAALDKATV ; 350: LLSMSKGGKR ; KDSVWGSGGG ; QQPVNHLVKE ; IDMLLKEYLL ; SGDMSEAEHC ; 400: LKELEVPHFH ; HELVYEAIVM ; VLESTGESAF ; KMMLDLLKSL ; WKSSTITIDQ ; 450: MKRGYERIYN ; EIPDINLDVP ; HSYSVLERFV ; EECFQAGIIS ; KQLRDLCPSR ; 469: GRKRFVSEGD ; GGRLKPESY
Sequence Length	469
String	Q9JID1
Sub Unit	Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.

Uniprot	Q9JID1
Gene Name	Pdcd4
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:64031
Unigene	Rn.206228

Reference	1. "DUG is a novel homologue of translation initiation factor 4G that binds eIF4A." Goeke A., Goeke R., Knolle A., Trusheim H., Schmidt H., Wilmen A., Carmody R., Goeke B., Chen Y.H. Biochem. Biophys. Res. Commun.297:78-82(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;INTERACTION WITH EIF4A1;INDUCTION;ALTERNATIVE SPLICING 2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites." Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A. Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808382	E2393r	96T	$796		Add to Cart

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