ELISA Kit for Rat Profilin-2

Mfr.No.	E0347r
Alternative Names	Profilin II
Categories	Elisa
Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Specificity	Natural and recombinant Rat Profilin-2
Subcellular Location	Cytoplasm cytoskeleton
Detection Range	0.312-20ng/mL
Entryname	PROF2_RAT
Method Type	Competitive
Platform	PF00235
Protein Name	Profilin-2
Sensitivity	0.1ng/mL
Sequence	50: MAGWQSYVDN ; LMCDGCCQEA ; AIVGYCDAKY ; VWAATAGGVF ; QSITPAEIDV ; 100: IIGKDREGFF ; TNGLTLGGKK ; CSVIRDSLYV ; DSDCTMDIRT ; KSQGGEPTYN ; 140: VAVGRAGRVL ; VFVMGKEGVH ; GGGLNKKAYS ; MAKYLRDSGF ;
Sequence Length	140
String	Q9EPC6
Sub Unit	Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Reference	1. "Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical properties." Lambrechts A., Braun A., Jonckheere V., Aszodi A., Lanier L.M., Robbens J., Van Colen I., Vandekerckhove J., Faessler R., Ampe C. Mol. Cell. Biol.20:8209-8219(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. 2. "Novel genes expression in rat brain." Xiao H., Huang Q., Zhang F., Yang Z., Chen Z., Han Z., Zhang X. Submitted (2000-03) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. 3. Lubec G., Afjehi-Sadat L., Chen W.-Q. Submitted (2007-04) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 55-69; 92-105 AND 109-116;IDENTIFICATION BY MASS SPECTROMETRY strain: Sprague-Dawley. tissue: Hippocampus. tissue: Spinal cord.

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