Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis. Both in normal development and in response to nerve transection, SCIP expression was transiently activated only during the period of rapid cell division that separates the premyelinating and myelinating phases of Schwann cell differentiation. In cotransfection assays, scip acted as a transcriptional repressor of myelin specific genes.
Specificity
Natural and recombinant Rat POU domain, class 3, transcription factor 1