Csk-binding protein ; Transmembrane phosphoprotein Cbp ; Cbp ; Pag
Categories
Elisa
Function
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Specificity
Natural and recombinant Rat Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Subcellular Location
Cell membrane Single-pass type III membrane protein Present in lipid rafts.
Entryname
PHAG1_RAT
Protein Name
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Interacts with SLC9A3R1/EBP50. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity). When phosphorylated, interacts with CSK. Identified in a complex with LYN and STAT3 (By similarity). Interacts with LYN.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH CSK;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF TYR-107; TYR-165; TYR-183; TYR-224; TYR-296; TYR-314; TYR-351; TYR-381 AND TYR-409;PHOSPHORYLATION AT TYR-314;FUNCTION
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-165; TYR-183; TYR-224; TYR-314; TYR-381 AND TYR-409;FUNCTION
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH CSK;PHOSPHORYLATION;FUNCTION
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CSK;PHOSPHORYLATION;MUTAGENESIS OF TYR-314
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LYN AND CSK;PHOSPHORYLATION AT TYR-107 AND TYR-314
Reviews of ELISA Kit for Rat Phosphoprotein associated with glycosphingolipid-enriched microdomains 1