Csk-binding protein ; Transmembrane phosphoprotein Cbp ; Cbp ; Pag
Categories
Elisa
Function
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Specificity
Natural and recombinant Rat Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Subcellular Location
Cell membrane Single-pass type III membrane protein Present in lipid rafts.
Entryname
PAG1_RAT
Protein Name
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Interacts with SLC9A3R1/EBP50. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity). When phosphorylated, interacts with CSK.