ELISA Kit for Rat Phospholipid hydroperoxide glutathione peroxidase, nuclear

Mfr.No.	E9951r
Antigen	GPX4
Alternative Names	Glutathione peroxidase 4 ; GPx-4
Categories	Elisa
Function	Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Stabilizes the condensed chromatin in sperm nuclei and is necessary male fertility.
Specificity	Natural and recombinant Rat Phospholipid hydroperoxide glutathione peroxidase, nuclear
Subcellular Location	Nucleus
Entryname	GPX42_RAT
Platform	PF00255
Protein Name	Phospholipid hydroperoxide glutathione peroxidase, nuclear
Sequence	50: MGRAAARKRG ; RCRQRGRSPG ; GRRRREPGRQ ; SPRKRPGPRR ; RRARARRRRR ; 100: ARPRRMEPIP ; EPFNPRPLLQ ; DLPQTSNSHE ; FLGLCASRDD ; WRCARSMHEF ; 150: AAKDIDGHMV ; CLDKYRGCVC ; IVTNVASQUG ; KTDVNYTQLV ; DLHARYAECG ; 200: LRILAFPCNQ ; FGRQEPGSNQ ; EIKEFAAGYN ; VRFDMYSKIC ; VNGDDAHPLW ; 250: KWMKVQPKGR ; GMLGNAIKWN ; FTKFLIDKNG ; CVVKRYGPME ; EPQVIEKDLP ; 253: CYL
Sequence Length	253
String	Q91XR8

Reference	1. "Distinct promoters determine alternative transcription of gpx-4 into PHGPx variants." Maiorino M., Scapin M., Ursini F., Biasolo M., Bosello V., Flohe L. Submitted (2003-01) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] strain: Wistar. 2. "Cloning of cDNA of rat phospholipid hydroperoxide/sperm nucleus glutathione peroxidase." Tramer F., Vetere A., Martinelli M., Paroni F., Marsich E., Sandri G., Panfili E. Submitted (2004-03) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Wistar. 3. "Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturation." Pfeifer H., Conrad M., Roethlein D., Kyriakopoulos A., Brielmeier M., Bornkamm G.W., Behne D. FASEB J.15:1236-1238(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-250;SUBCELLULAR LOCATION tissue: Testis.

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