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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Peptidyl-prolyl cis-trans isomerase FKBP4

SKU : BHE13804052

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11170r
Alternative Names	52 kDa FK506-binding protein ; 52 kDa FKBP ; 59 kDa immunophilin ; p59 ; FK506-binding protein 4 ; FKBP-4 ; FKBP59 ; HSP-binding immunophilin ; HBI ; Immunophilin FKBP52 ; Rotamase ; Fkbp52
Categories	Elisa
Function	Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) (By similarity). Play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. The PPIase activity controls neuronal growth cones via regulation of TRPC1 channel opening.
Specificity	Natural and recombinant Rat Peptidyl-prolyl cis-trans isomerase FKBP4
Subcellular Location	Cytoplasm cytosol Nucleus Cytoplasm cytoskeleton Colocalized with MAPT/TAU in the distal part of the primary cortical neurons.
Entryname	FKBP4_RAT
Platform	PF00254
Protein Name	Peptidyl-prolyl cis-trans isomerase FKBP4
Sequence	50: MTAEEMKVAE ; NGAQSAPLPL ; EGVDISPKQD ; EGVLKVIKRE ; GTGTETAMIG ; 100: DRVFVHYTGW ; LLDGTKFDSS ; LDRKDKFSFD ; LGKGEVIKAW ; DIAVATMKVG ; 150: EVCHITCKPE ; YAYGSAGSPP ; KIPPNATLVF ; EVELFEFKGE ; DLTEDEDGGI ; 200: IRRIRTRGEG ; YARPNDGAMV ; EVALEGYYND ; RLFDQRELCF ; EVGEGESLDL ; 250: PCGLEEAIQR ; MEKGEHSIVY ; LKPSYAFGSV ; GKERFQIPPH ; AELRYEVHLK ; 300: SFEKAKASWE ; MNSEEKLEQS ; NIVKERGTVY ; FKEGKYKQAL ; LQYKKIVSWL ; 350: EYESSFSGEE ; MQKVHALRLA ; SHLNLAMCHL ; KLQAFSAAIE ; SCNKALELDS ; 400: NNEKGLFRRG ; EAHLAVNDFD ; LARADFQKVL ; QLYPSNKAAK ; TQLAVCQQRT ; 450: RRQLAREKKL ; YANMFERLAE ; EEHKAKTEVA ; AGDHPTDAEM ; KGEPNNVAGN ; 458: QAQVKTEA
Sequence Length	458
String	Q9QVC8
Sub Unit	Homodimer (By similarity). Associates (via TPR domains) with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH) (By similarity). Interacts with NR3C1 and dynein. Interacts with HSF1 in the HSP90 complex (By similarity). Associates with tubulin (By similarity). Interacts with MAPT/TAU; the interaction is enhanced for phosphorylated MAPT/TAU. Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent (By similarity). Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction.

Uniprot	Q9QVC8
Gene Name	Fkbp4
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:260321
Unigene	Rn.23741

Reference	1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (2005-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 2. "Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex." Tai P.-K.K., Albers M.W., Chang H., Faber L.E., Schreiber S.L. Science256:1315-1318(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-25 tissue: Leukemia. 3. Desai B.J., McKinney K.Q., Meyer M.H., Bahrani-Mostafavi Z., Meyer R.A. Jr. Submitted (2002-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-458 strain: Sprague-Dawley. tissue: Brain. 4. "The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation." Chambraud B., Belabes H., Fontaine-Lenoir V., Fellous A., Baulieu E.E. FASEB J.21:2787-2797(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH TUBULIN 5. "A role for FKBP52 in Tau protein function." Chambraud B., Sardin E., Giustiniani J., Dounane O., Schumacher M., Goedert M., Baulieu E.E. Proc. Natl. Acad. Sci. U.S.A.107:2658-2663(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH MAPT 6. Maurya D.K., Bhargava P. Submitted (2009-01) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY

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