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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Numb-like protein

SKU : BHE13806535

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3117r
Alternative Names	Nbl
Categories	Elisa
Function	Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
Specificity	Natural and recombinant Rat Numb-like protein
Subcellular Location	Cytoplasm Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.
Entryname	NUMBL_RAT
Platform	PF06311
Protein Name	Numb-like protein
Sequence	50: MSRSAAASGG ; PRRPDQHLPP ; APCGASGPPE ; TFRTESDGAG ; TMNKLRQSLR ; 100: RRKPAYVPEA ; SRPHQWQADE ; DAVRKGTCSF ; PVRYLGHVEV ; EESRGMHVCE ; 150: DAVKKLKAMG ; RKSVKSVLWV ; SADGLRVVDD ; KTKDLLVDQT ; IEKVSFCAPD ; 200: RNLDKAFSYI ; CRDGTTRRWI ; CHCFLALKDS ; GERLSHAVGC ; AFAACLERKQ ; 250: RREKECGVTA ; AFDASRTSFA ; REGSFRLSGG ; GRPAEREAGD ; KKKAEAAAAP ; 300: AVAPGPAQPG ; HVSPTPATTS ; PGEKGEAGTP ; VAAGTTAAAI ; PRRHAPLEQL ; 350: VRQGSFRGFP ; ALSQKNSPFK ; RQLSLRLNEL ; PSTLQRRTDF ; QVKGTVPEME ; 400: PPGTGDSDGI ; SALCTQISSS ; FASAGAPVPG ; PPSATTGTSA ; WGEPSVPAAT ; 450: AFQPGHKRTP ; SEAERWLEEV ; SQVAKAQQQQ ; QQQQQQQQQQ ; QQQQQQQQQQ ; 500: QATSVPPMPT ; MAPTLQPFST ; PVGPFDTAAA ; QVAVFLPPTH ; MQPPFVPAYP ; 550: GLGYPPMPRV ; PVVGITPSQM ; VANAFCSAAQ ; LQPQPATLLG ; KAGAFPPPTA ; 600: PSAPGGQARP ; RPNGAPWPPE ; PAPAPAPELD ; PFEAQWAALE ; GKPAVEKPSN ; 614: PFSGDLQKTF ; EIEL
Sequence Length	614
String	A1L1I3
Sub Unit	Associates with EPS15 and NOTCH1 (By similarity). Interacts (via PTB domain) with MAP3K7IP2 (via C-terminal). Interacts (via C-terminal) with TRAF6 (via TRAF domains).

Uniprot	A1L1I3
Gene Name	Numbl
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.15133

Reference	1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (2005-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: Brown Norway. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Heart. 3. "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation." Ma Q., Zhou L., Shi H., Huo K. Cell. Signal.20:1044-1051(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NUMBL 4. "NUMBL interacts with TRAF6 and promotes the degradation of TRAF6." Zhou L., Ma Q., Shi H., Huo K. Biochem. Biophys. Res. Commun.392:409-414(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NUMBL

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806535	E3117r	96T	$796		Add to Cart

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