Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.
Specificity
Natural and recombinant Rat Nuclear factor of activated T-cells 5
Subcellular Location
Nucleus Cytoplasm Nuclear distribution increases under hypertonic conditions.
Homodimer when bound to DNA, completely encircles its DNA target. Does not bind with Fos and Jun transcription factors (By similarity). Interacts with CIDEC; this interaction is direct and retains NFAT5 in the cytoplasm.