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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat NAD-dependent protein deacylase sirtuin-5, mitochondrial

SKU : BHE13809172

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11384r
Alternative Names	Regulatory protein SIR2 homolog 5 ; SIR2-like protein 5
Categories	Elisa
Function	NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.
Specificity	Natural and recombinant Rat NAD-dependent protein deacylase sirtuin-5, mitochondrial
Subcellular Location	Mitochondrion Cytoplasm Cytosol Nucleus Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus.
Detection Range	0.156-10ng/mL
Entryname	SIR5_RAT
Method Type	Sandwich
Platform	PF02146
Protein Name	NAD-dependent protein deacylase sirtuin-5, mitochondrial
Sensitivity	0.057ng/mL
Sequence	50: MRPLPVAPGR ; LFSQLCCGPK ; PSASPQSKIC ; LTMARPSSNM ; ADFRKCFANA ; 100: KHIVIISGAG ; VSAESGVPTF ; RGTGGYWRKW ; QAQHLATPLA ; FAHNPSQVWE ; 150: FYHYRREVMR ; NKEPNPGHLA ; IAQCEARLRD ; QGRRVVVITQ ; NIDELHRKAG ; 200: TKNLLEIHGT ; LFKTRCTSCG ; NVAENYKSPI ; CPALLGKGAP ; EPDTQESRIP ; 250: VHKLPRCEEA ; GCGGLLRPHV ; VWFGENLDPA ; ILKEVDRELA ; RCDLCLVVGT ; 300: SSVVYPAAMF ; APQVASRGVP ; VAEFNMETTP ; ATNRFRFHFP ; GPCGVTLPEA ; 310: LAPHETERIS ;
Sequence Length	310
Sub Unit	Monomer. Homodimer. Interacts with CPS1.

Uniprot	Q68FX9
Gene Name	Sirt5
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:306840
Unigene	Rn.137920

Reference	1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Kidney.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809172	E11384r	96T	$796		Add to Cart

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