UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
Specificity
Natural and recombinant Rat Mitochondrial uncoupling protein 3
Subcellular Location
Mitochondrion inner membrane Multi-pass membrane protein
"Lipopolysaccharide treatment increases thermogenesis and induces uncoupling protein-3 gene expression in skeletal muscle." Solanes G., Valet P., Lowell B.B. Submitted (1997-10) to the EMBL/GenBank/DDBJ databases
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