ELISA Kit for Rat Lysophosphatidic acid receptor 1

Mfr.No.	E9739r
Alternative Names	Lysophosphatidic acid receptor Edg-2 ; Edg2 ; Gpcr91 ; Lpa1
Categories	Elisa
Function	Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.
Specificity	Natural and recombinant Rat Lysophosphatidic acid receptor 1
Subcellular Location	Cell surface Cell membrane Multi-pass membrane protein Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles.
Detection Range	0.312-20ng/mL
Entryname	LPAR1_RAT
Method Type	Sandwich
Platform	PF00001
Protein Name	Lysophosphatidic acid receptor 1
Sensitivity	0.156ng/mL
Sequence	50: MAAASTSSPV ; ISQPQFTAMN ; EQQCFYNESI ; AFFYNRSGKY ; LATEWNTVSK ; 100: LVMGLGITVC ; VFIMLANLLV ; MVAIYVNRRF ; HFPIYYLMAN ; LAAADFFAGL ; 150: AYFYLMFNTG ; PNTRRLTVST ; WLLRQGLIDT ; SLTASVANLL ; AIAIERHITV ; 200: FRMQLHTRMS ; NRRVVVVIVV ; IWTMAIVMGA ; IPSVGWNCIC ; DIDHCSNMAP ; 250: LYSDSYLVFW ; AIFNLVTFVV ; MVVLYAHIFG ; YVRQRTMRMS ; RHSSGPRRNR ; 300: DTMMSLLKTV ; VIVLGAFIVC ; WTPGLVLLLL ; DVCCPQCDVL ; AYEKFFLLLA ; 350: EFNSAMNPII ; YSYRDKEMSA ; TFRQILCCQR ; NENPNGPTEG ; SDRSASSLNH ; 364: TILAGVHSND ; HSVV
Sequence Length	364
String	P61794
Sub Unit	Interacts with RALA and ADRBK1.

Reference	1. "A rat G protein-coupled receptor selectively expressed in myelin-forming cells." Allard J., Barron S., Diaz J., Lubetzki C., Zalc B., Schwartz J.-C., Sokoloff P. Eur. J. Neurosci.10:1045-1053(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Olfactory bulb. 2. "Identification and characterization of novel G-protein coupled receptors expressed in regenerating peripheral nerve." Carroll S.L., Miller M.L., Benedict-Hamilton H.M. Submitted (1998-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Brain.

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