ELISA Kit for Rat Lymphoid enhancer-binding factor 1

Mfr.No.	E15267r
Categories	Elisa
Function	Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1.
Specificity	Natural and recombinant Rat Lymphoid enhancer-binding factor 1
Subcellular Location	Nucleus Found in nuclear bodies upon PIASG binding.
Detection Range	78-5000pg/mL
Entryname	LEF1_RAT
Method Type	Sandwich
Platform	PF08347
Protein Name	Lymphoid enhancer-binding factor 1
Sensitivity	49pg/mL
Sequence	50: MPQLSGGGGG ; GDPELCATDE ; MIPFKDEGDP ; QKEKIFAEIS ; HPEEEGDLAD ; 100: IKSSLVNESE ; IIPASNGHEV ; VGQTQSSQEP ; YHDKAREHPD ; DGKHPDGGLY ; 150: NKGPSYSSYS ; GYIMMPNMNS ; DPYMSNGSLS ; PPIPRTSNKV ; PVVQPSHAVH ; 200: PLTPLITYSD ; EHFSPGSHPS ; HIPSEVNPKQ ; GMSRHPPAPE ; MPTFYPLSPG ; 250: GVGQITPPLG ; WQGQPVYPIT ; GGFRQAYPSS ; LSGDTSMSRF ; SHHMIPGPPG ; 300: PHTTGIPHPA ; IVTPQVKQEH ; PHTDSDLMHV ; KPEHEQRKEQ ; EPKRPHIKKP ; 350: LNAFMLYMKE ; MRANVVAECT ; LKESAAINQI ; LGRRWHALSR ; EEQAKYYELA ; 397: RKERQLHMQL ; YPGWSARDNY ; GKKKKRKREK ; LQESTSGTGP ; RMTAAYI
Sequence Length	397
String	Q9QXN1
Sub Unit	Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with TLE1, PIASG, THOC4, EP300, MDFI and MDFIC.

Reference	1. "Cloning of the lymphoid enhancer binding factor-1 (Lef-1) cDNA from rat kidney: homology to the mouse sequence." Kobielak K., Kobielak A., Trzeciak W.H. Acta Biochim. Pol.46:885-888(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Kidney.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806892	E15267r	96T	$796		Add to Cart