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ELISA Kit for Rat Large proline-rich protein BAG6

SKU : BHE13801802

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14404r
Alternative Names	BCL2-associated athanogene 6 ; HLA-B-associated transcript 3 ; Bat3
Categories	Elisa
Function	Chaperone that plays a key role in various processes such as apoptosis, insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane and regulation of chromatin. Acts in part by regulating stability of proteins and their degradation by the proteasome. Participates in endoplasmic reticulum stress-induced apoptosis via its interaction with AIFM1/AIF by regulating AIFM1/AIF stability and preventing its degradation. Also required during spermatogenesis for synaptonemal complex assembly via its interaction with HSPA2, by inhibiting polyubiquitination and subsequent proteasomal degradation of HSPA2. Required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, may play a role in immuno-proteasomes to generate antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response. Key component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins and transfers them to ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane. Also involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2).
Specificity	Natural and recombinant Rat Large proline-rich protein BAG6
Subcellular Location	Cytoplasm cytosol Nucleus The C-terminal fragment generated by caspase-3 is cytoplasmic.
Detection Range	0.312-20ng/mL
Entryname	BAG6_RAT
Method Type	Sandwich
Platform	PF12057
Protein Name	Large proline-rich protein BAG6
Sensitivity	0.156ng/mL
Sequence	50: MEPSDSTSTA ; MEEPDSLEVL ; VKTLDSQTRT ; FIVGAQMNVK ; EFKEHIAASV ; 100: SIPSEKQRLI ; YQGRVLQDDK ; KLQDYNVGGK ; VIHLVERAPP ; QTQLPSGASS ; 150: GTGSASATHG ; GGPLPGTRGP ; GASGHDRNAN ; SYVMVGTFNL ; PSDGSAVDVH ; 200: INMEQAPIQS ; EPRVRLVMAQ ; HMIRDIQTLL ; SRMECRGGTQ ; AQASQPPPQT ; 250: PTVASETVAL ; NSQTSEPVES ; EAPPREPMES ; EEMEERPPTQ ; TPELPPSGPA ; 300: PAGPAPAPET ; NAPNHPSPAE ; HVEVLQELQR ; LQRRLQPFLQ ; RYCEVLGAAA ; 350: TTDYNNNHEG ; REEDQRLINL ; VGESLRLLGN ; TFVALSDLRC ; NLACAPPRHL ; 400: HVVRPMSHYT ; TPMVLQQAAI ; PIQINVGTTV ; TMTGNGARPP ; PAPGAEAASP ; 450: GSGQASSLPP ; SSATVDSSTE ; GAPPPGPAPP ; PATSHPRVIR ; ISHQSVEPVV ; 500: MMHMNIQDSG ; AQPGGVPSAP ; TGPLGPPGHG ; QSLGQQVPGF ; PTAPTRVVIA ; 550: RPTPPQARPS ; HPGGPPVSGA ; LQGAGLGTNT ; SLAQMVSGLV ; GQLLMQPVLV ; 600: AQGTPGMAPA ; SASAPATAQA ; QAPAPAPAPA ; PAPATASASA ; GTTNTATTAG ; 650: PAPGGPAQPP ; PPQPSAADLQ ; FSQLLGNLLG ; PAGPGAGGPS ; LASPTITVAV ; 700: PGVPAFLQGM ; TEFLQASQAA ; PPPPPPPPPP ; PPAPEQQTTP ; PPGSPSGGTA ; 750: SPGGLGPESL ; PPEFFTSVVQ ; GVLSSLLGSL ; GARAGSSESI ; AAFIQRLSGS ; 800: SNIFEPGADG ; ALGFFGALLS ; LLCQNFSMVD ; VVMLLHGHFQ ; PLQRLQPQLR ; 850: SFFHQHYLGG ; QEPTSSNIRM ; ATHTLITGLE ; EYVRESFSLV ; QVQPGVDIIR ; 900: TNLEFLQEQF ; NSIAAHVLHC ; TDSGFGARLL ; ELCNQGLFEC ; LALNLHCLGG ; 950: QQMELAAVIN ; GRIRRMSRGV ; NPSLVSWLTT ; MMGLRLQVVL ; EHMPVGPDAI ; 1000: LRYVRRIGDP ; PQALPEEPME ; VQGAERTSPE ; PQREDASPAP ; GTTAEEAMSR ; 1050: GPPPAPEGGS ; RDEQDGASAD ; AEPWAAAVPP ; EWVPIIQQDI ; QSQRKVKPQP ; 1100: PLSDAYLSGM ; PAKRRKTMQG ; EGPQLLLSEA ; VSRAAKAAGA ; RPLTSPESLS ; 1146: RDLEAPEVQE ; SYRQQLRSDI ; QKRLQEDPNY ; SPQRFPNAHR ; AFADDP
Sequence Length	1146
String	Q6MG49
Sub Unit	Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET3/TRC35. Interacts with AIFM1, CTCFL, HSPA2 and p300/EP300. Interacts with ricin A chain.

Uniprot	Q6MG49
Gene Name	Bag6
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:94342
Unigene	Rn.203343

Reference	1. "Cloning and characterization of rat BAT3 cDNA." Ozaki T., Hanaoka E., Naka M., Nakagawara A., Sakiyama S. DNA Cell Biol.18:503-512(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) 2. "The genomic sequence and comparative analysis of the rat major histocompatibility complex." Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H. Genome Res.14:631-639(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: Brown Norway. 3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (2005-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: Brown Norway. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) tissue: Brain.

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