Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
Specificity
Natural and recombinant Rat Kynurenine 3-monooxygenase
Subcellular Location
Mitochondrion outer membrane Multi-pass membrane protein
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;SUBCELLULAR LOCATION;TISSUE SPECIFICITY