Kin of irregular chiasm-like protein 1 ; Nephrin-like protein 1 ; Kirrel1 ; Neph1
Categories
Elisa
Function
Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Specificity
Natural and recombinant Rat Kin of IRRE-like protein 1
Subcellular Location
Cell membrane Single-pass type I membrane protein Predominantly located at podocyte slit diaphragm.
Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains).