May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1).
Specificity
Natural and recombinant Rat Keratin, type II cytoskeletal 1
Heterotetramer of two type I and two type II keratins. Keratin-1 is generally associated with keratin-10. Interacts with ITB1 in the presence of GNB2L1 and SRC, and with GNB2L1.