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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Integrin beta-1

SKU : BHE13806250

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2224r
Alternative Names	Beta oligodendroglia ; Beta OL ; Fibronectin receptor subunit beta ; VLA-4 subunit beta ; CD29
Categories	Elisa
Function	Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1, serves as a platform for SRC activation or inactivation (By similarity). Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis.
Specificity	Natural and recombinant Rat Integrin beta-1
Subcellular Location	Cell membrane Single-pass type I membrane protein Melanosome
Detection Range	31.2-2000pg/mL
Entryname	ITB1_RAT
Method Type	Sandwich
Platform	PF07974
Protein Name	Integrin beta-1
Sensitivity	15.81pg/mL
Sequence	50: MNLQLVFWIG ; LISLICSVFG ; QTDKNRCLKA ; NAKSCGECIQ ; AGPNCGWCTN ; 100: TTFLQEGMPT ; SARCDDLEAL ; KKKGCHPSDI ; ENPRGSQTIK ; KNKNVTNRSK ; 150: GMAEKLRPED ; ITQIQPQQLL ; LKLRSGEPQK ; FTLKFKRAED ; YPIDLYYLMD ; 200: LSYSMKDDLE ; NVKSLGTDLM ; NEMRRITSDF ; RIGFGSFVEK ; TVMPYISTTP ; 250: AKLRNPCTSE ; QNCTSPFSYK ; NVLSLTDRGE ; FFNELVGQQR ; ISGNLDSPEG ; 300: GFDAIMQVAV ; CGSLIGWRNV ; TRLLVFSTDA ; GFHFAGDGKL ; GGIVLPNDGQ ; 350: CHLENNVYTM ; SHYYDYPSIA ; HLVQKLSENN ; IQTIFAVTEE ; FQPVYKELKN ; 400: LIPKSAVGTL ; SGNSSNVIQL ; IIDAYNSLSS ; EVILENSKLP ; DGVTINYKSY ; 450: CKNGVNGTGE ; NGRKCSNISI ; GDEVQFEISI ; TANKCPNKES ; ENQLKLNPLG ; 500: FTEEVEVVLQ ; FICKCNCQSH ; GIPASPKCHE ; GNGTFECGAC ; RCNEGRVGRH ; 550: CECSTDEVNS ; EDMDAYCRKE ; NSSEICSNNG ; ECVCGQCVCR ; KRENTNEIYS ; 600: GKFCECDNFN ; CDRSNGLICG ; GNGVCRCRVC ; ECYPNYTGSA ; CDCSLDTVPC ; 650: VATNGQICNG ; RGICECGACK ; CTDPKFQGPT ; CETCQTCLGV ; CAEHKECVQC ; 700: RAFNKGEKKD ; TCAQECSHFN ; LTKVESREKL ; PQPVQVDPVT ; HCKEKDIDDC ; 750: WFYFTYSVNS ; KGEAHVHVVE ; TPDCPTGPDI ; IPIVAGVVAG ; IVLIGLALLL ; 799: IWKLLMIIHD ; RREFAKFEKE ; KMNAKWDTGE ; NPIYKSAVTT ; VVNPKYEGK
Sequence Length	799
String	P49134
Sub Unit	Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB, FLNC and RANBP9. Interacts with KRT1 in the presence of GNB2L1 and SRC (By similarity). Interacts with RAB21. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with FGR.

Uniprot	P49134
Gene Name	Itgb1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:24511
Unigene	Rn.25733

Reference	1. "Cloning and sequence of the cDNA encoding the rat oligodendrocyte integrin beta 1 subunit." Malek-Hedayat S., Rome L.H. Gene158:287-290(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Oligodendrocyte. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Brain.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806250	E2224r	96T	$796		Add to Cart

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